Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
J Endocrinol Invest. 2018 May;41(5):597-607. doi: 10.1007/s40618-017-0785-9. Epub 2017 Nov 6.
Polycystic ovary syndrome (PCOS) is known as the most common endocrine disorder in reproductive age women. The aim of this studywas to evaluate the effects of vitamin D supplementation in combination with low-calorie diet on anthropometric indices, reproductive hormones and menstrual regularity in overweight and obese PCOS women.
In this randomized controlled clinical trial, 60 PCOS women with vitamin D insufficiency were randomly assigned to 12 weeks of either (1) weight-loss intervention + 50,000 IU/week oral vitamin D3 or (2) weight-loss intervention + placebo. At the beginning and end of the study, the anthropometric indices, body composition, 25-hydroxyvitamin D, total testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG) and free androgen index (FAI) were measured and regularity of menses was compared among the two groups.
After 12-week intervention, median of serum 25-hydroxyvitamin D3 significantly increased from 18.5 (10.75-20) ng/ml to 42.69 (34-53.25) ng/ml in vitamin D group compared to placebo group (p < 001). Moreover, there was a significant improvement in frequency regular menstrual cycle (p = 0.01). Mean of weight, body mass index, fat mass, waist and hip circumference and waist-to-hip ratio significantly decreased in both groups, but was not different between two groups. Mean of total testosterone insignificantly decreased from 0.7 to 0.5 ng/ml in vitamin D group (p = 0.18). In addition, we did not observe significant differences regarding DHEAS, FAI and SHBG between two groups.
In women with PCOS, androgen profile did not change with vitamin D supplementation when combined with low-calorie diet, but menstrual frequency significantly improved.
IRCT2016062710826N19.
多囊卵巢综合征（PCOS）是生殖年龄妇女中最常见的内分泌疾病。本研究旨在评估维生素 D 补充联合低热量饮食对超重和肥胖 PCOS 妇女的人体测量指标、生殖激素和月经规律的影响。
在这项随机对照临床试验中，将 60 名维生素 D 不足的 PCOS 妇女随机分为 12 周的减肥干预+每周 50,000IU 口服维生素 D3 或减肥干预+安慰剂。在研究开始和结束时，测量人体测量指标、身体成分、25-羟维生素 D、总睾酮、脱氢表雄酮硫酸酯（DHEAS）、性激素结合球蛋白（SHBG）和游离雄激素指数（FAI），并比较两组之间的月经规律。
干预 12 周后，与安慰剂组相比，维生素 D 组血清 25-羟维生素 D3 的中位数从 18.5（10.75-20）ng/ml 显著增加到 42.69（34-53.25）ng/ml（p<0.001）。此外，月经周期规律的频率也有显著改善（p=0.01）。两组的体重、体重指数、脂肪量、腰围和臀围以及腰臀比均显著下降，但两组间无差异。维生素 D 组的总睾酮均值从 0.7 降至 0.5ng/ml，但差异无统计学意义（p=0.18）。此外，两组间 DHEAS、FAI 和 SHBG 无显著差异。
在 PCOS 妇女中，维生素 D 补充联合低热量饮食不会改变雄激素谱，但月经频率显著改善。
IRCT2016062710826N19。
