• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

海洋甲壳素材料的微生物转化用于生产 α-葡萄糖苷酶抑制剂的回收。

Reclamation of Marine Chitinous Materials for the Production of α-Glucosidase Inhibitors via Microbial Conversion.

机构信息

Department of Science and Technology, Tay Nguyen University, Buon Ma Thuot City 630000, Vietnam.

Department of Chemistry, Tamkang University, New Taipei City 25137, Taiwan.

出版信息

Mar Drugs. 2017 Nov 7;15(11):350. doi: 10.3390/md15110350.

DOI:10.3390/md15110350
PMID:29112160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5706040/
Abstract

Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (deSSP) as the C/N source. The half maximal inhibitory concentration (IC) and maximum aGI activity of fermented deCSP (38 µg/mL, 98%), deSSP (108 µg/mL, 89%), squid pen powder (SPP) (422 µg/mL, 98%), and shrimp head powder (SHP) (455 µg/mL, 92%) were compared with those of fermented nutrient broth (FNB) (81 µg/mL, 93%) and acarbose (1095 µg/mL, 74%), a commercial antidiabetic drug. The result of the protein/chitin ratio on aGI production showed that the optimal ratio was 0.2/1. Fermented deCSP showed lower IC and higher maximum inhibitory activity than those of acarbose against rat intestinal α-glucosidase.

摘要

六种壳质材料已被用于 sp. TKU042 生产α-葡萄糖苷酶抑制剂（aGI）的唯一碳/氮（C/N）源。发现以去矿化蟹壳粉（deCSP）和去矿化虾壳粉（deSSP）作为 C/N 源时，其发酵上清液中 aGI 的产率最高。发酵 deCSP（半抑制浓度（IC）为 38 µg/mL，最大酶活为 98%）、deSSP（IC 为 108 µg/mL，最大酶活为 89%）、鱿鱼笔粉（SPP）（IC 为 422 µg/mL，最大酶活为 98%）和虾头粉（SHP）（IC 为 455 µg/mL，最大酶活为 92%）的半最大抑制浓度（IC）和最大 aGI 活性与发酵营养肉汤（FNB）（IC 为 81 µg/mL，最大酶活为 93%）和阿卡波糖（商业抗糖尿病药物，IC 为 1095 µg/mL，最大酶活为 74%）进行了比较。蛋白/壳质比在 aGI 生产中的结果表明，最佳比例为 0.2/1。发酵 deCSP 对大鼠肠道α-葡萄糖苷酶的 IC 低于阿卡波糖，最大抑制活性高于阿卡波糖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f2/5706040/0c8ae5680a23/marinedrugs-15-00350-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f2/5706040/fd7c4f5d759d/marinedrugs-15-00350-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f2/5706040/0fdc37e8dec8/marinedrugs-15-00350-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f2/5706040/0c8ae5680a23/marinedrugs-15-00350-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f2/5706040/fd7c4f5d759d/marinedrugs-15-00350-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f2/5706040/0fdc37e8dec8/marinedrugs-15-00350-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20f2/5706040/0c8ae5680a23/marinedrugs-15-00350-g003.jpg

相似文献

1
Reclamation of Marine Chitinous Materials for the Production of α-Glucosidase Inhibitors via Microbial Conversion.海洋甲壳素材料的微生物转化用于生产 α-葡萄糖苷酶抑制剂的回收。
Mar Drugs. 2017 Nov 7;15(11):350. doi: 10.3390/md15110350.
2
Utilization of Fishery Processing By-Product Squid Pens for α-Glucosidase Inhibitors Production by Paenibacillus sp.利用渔业加工副产物鱿鱼笔生产 Paenibacillus sp. 的α-葡萄糖苷酶抑制剂
Mar Drugs. 2017 Aug 30;15(9):274. doi: 10.3390/md15090274.
3
Conversion of Squid Pens to Chitosanases and Proteases via Paenibacillus sp. TKU042.鱿鱼墨经 Paenibacillus sp. TKU042 转化为壳聚糖酶和蛋白酶。
Mar Drugs. 2018 Mar 8;16(3):83. doi: 10.3390/md16030083.
4
Production and Bioactivity-Guided Isolation of Antioxidants with α-Glucosidase Inhibitory and Anti-NO Properties from Marine Chitinous Materials.从海洋几丁质材料中生产具有α-葡萄糖苷酶抑制和抗 NO 活性的抗氧化剂及其生物活性导向分离。
Molecules. 2018 May 9;23(5):1124. doi: 10.3390/molecules23051124.
5
Biosynthesis of α-Glucosidase Inhibitors by a Newly Isolated Bacterium, Paenibacillus sp. TKU042 and Its Effect on Reducing Plasma Glucose in a Mouse Model.新分离细菌芽孢杆菌属菌株Paenibacillus sp. TKU042合成α-葡萄糖苷酶抑制剂及其对小鼠模型血浆葡萄糖降低的影响
Int J Mol Sci. 2017 Mar 25;18(4):700. doi: 10.3390/ijms18040700.
6
Proteases Production and Chitin Preparation from the Liquid Fermentation of Chitinous Fishery By-Products by .利用甲壳素水产加工副产物的液体发酵生产蛋白酶和制备甲壳素。
Mar Drugs. 2021 Aug 25;19(9):477. doi: 10.3390/md19090477.
7
Conversion of Squid Pen to Homogentisic Acid via Paenibacillus sp. TKU036 and the Antioxidant and Anti-Inflammatory Activities of Homogentisic Acid.通过芽孢杆菌属菌株TKU036将鱿鱼笔转化为尿黑酸及其尿黑酸的抗氧化和抗炎活性
Mar Drugs. 2016 Oct 12;14(10):183. doi: 10.3390/md14100183.
8
Production of a Thermostable Chitosanase from Shrimp Heads via TKU032 Conversion and its Application in the Preparation of Bioactive Chitosan Oligosaccharides.虾头来源耐热壳聚糖酶的 TKU032 转化生产及其在生物活性壳寡糖制备中的应用。
Mar Drugs. 2019 Apr 10;17(4):217. doi: 10.3390/md17040217.
9
Anti-α-Glucosidase Activity by a Protease from .α-葡萄糖苷酶抑制活性的蛋白酶从 。
Molecules. 2019 Feb 15;24(4):691. doi: 10.3390/molecules24040691.
10
Utilization of Seafood Processing By-Products for Production of Proteases by sp. TKU052 and Their Application in Biopeptides' Preparation.利用 sp. TKU052 生产蛋白酶的海鲜加工副产物及其在生物活性肽制备中的应用。
Mar Drugs. 2020 Nov 20;18(11):574. doi: 10.3390/md18110574.

引用本文的文献

1
Research Progress of α-Glucosidase Inhibitors Produced by Microorganisms and Their Applications.微生物产生的α-葡萄糖苷酶抑制剂的研究进展及其应用
Foods. 2023 Sep 6;12(18):3344. doi: 10.3390/foods12183344.
2
Hypoglycaemic Molecules for the Management of Diabetes Mellitus from Marine Sources.用于管理糖尿病的海洋来源降血糖分子。
Diabetes Metab Syndr Obes. 2023 Jul 25;16:2187-2223. doi: 10.2147/DMSO.S390741. eCollection 2023.
3
Novel α-Amylase Inhibitor Hemi-Pyocyanin Produced by Microbial Conversion of Chitinous Discards.

本文引用的文献

1
Utilization of Fishery Processing By-Product Squid Pens for α-Glucosidase Inhibitors Production by Paenibacillus sp.利用渔业加工副产物鱿鱼笔生产 Paenibacillus sp. 的α-葡萄糖苷酶抑制剂
Mar Drugs. 2017 Aug 30;15(9):274. doi: 10.3390/md15090274.
2
Biosynthesis of α-Glucosidase Inhibitors by a Newly Isolated Bacterium, Paenibacillus sp. TKU042 and Its Effect on Reducing Plasma Glucose in a Mouse Model.新分离细菌芽孢杆菌属菌株Paenibacillus sp. TKU042合成α-葡萄糖苷酶抑制剂及其对小鼠模型血浆葡萄糖降低的影响
Int J Mol Sci. 2017 Mar 25;18(4):700. doi: 10.3390/ijms18040700.
3
Conversion of Squid Pen to Homogentisic Acid via Paenibacillus sp. TKU036 and the Antioxidant and Anti-Inflammatory Activities of Homogentisic Acid.
新型α-淀粉酶抑制剂——微生物转化甲壳质废料生成的半绿脓菌素。
Mar Drugs. 2022 Apr 23;20(5):283. doi: 10.3390/md20050283.
4
Production of Thermophilic Chitinase by sp. TKU052 by Bioprocessing of Chitinous Fishery Wastes and Its Application in -acetyl-D-glucosamine Production.嗜热栖热菌属菌株TKU052通过甲壳质渔业废料生物处理生产嗜热几丁质酶及其在N-乙酰-D-葡萄糖胺生产中的应用
Polymers (Basel). 2021 Sep 9;13(18):3048. doi: 10.3390/polym13183048.
5
Bioprocessing of Marine Chitinous Wastes for the Production of Bioactive Prodigiosin.海洋甲壳废物的生物加工生产生物活性普罗布考。
Molecules. 2021 May 24;26(11):3138. doi: 10.3390/molecules26113138.
6
Utilization of Seafood Processing By-Products for Production of Proteases by sp. TKU052 and Their Application in Biopeptides' Preparation.利用 sp. TKU052 生产蛋白酶的海鲜加工副产物及其在生物活性肽制备中的应用。
Mar Drugs. 2020 Nov 20;18(11):574. doi: 10.3390/md18110574.
7
Utilization of Crab Waste for Cost-Effective Bioproduction of Prodigiosin.利用蟹废物进行经济高效的灵菌红素生物生产。
Mar Drugs. 2020 Oct 22;18(11):523. doi: 10.3390/md18110523.
8
Microbial Conversion of Shrimp Heads to Proteases and Chitin as an Effective Dye Adsorbent.虾头微生物转化为蛋白酶和几丁质作为一种有效的染料吸附剂。
Polymers (Basel). 2020 Sep 28;12(10):2228. doi: 10.3390/polym12102228.
9
Production and Potential Applications of Bioconversion of Chitin and Protein-Containing Fishery Byproducts into Prodigiosin: A Review.甲壳素和含蛋白的水产副产物生物转化生产原卟啉及其潜在应用：综述。
Molecules. 2020 Jun 13;25(12):2744. doi: 10.3390/molecules25122744.
10
Microbial Reclamation of Chitin and Protein-Containing Marine By-Products for the Production of Prodigiosin and the Evaluation of Its Bioactivities.几丁质和含蛋白质海洋副产物的微生物回收用于灵菌红素的生产及其生物活性评估
Polymers (Basel). 2020 Jun 10;12(6):1328. doi: 10.3390/polym12061328.
通过芽孢杆菌属菌株TKU036将鱿鱼笔转化为尿黑酸及其尿黑酸的抗氧化和抗炎活性
Mar Drugs. 2016 Oct 12;14(10):183. doi: 10.3390/md14100183.
4
An Amphiprotic Novel Chitosanase from Bacillus mycoides and Its Application in the Production of Chitooligomers with Their Antioxidant and Anti-Inflammatory Evaluation.一种来自蕈状芽孢杆菌的两性新型壳聚糖酶及其在壳寡糖生产中的应用与抗氧化和抗炎评价
Int J Mol Sci. 2016 Aug 10;17(8):1302. doi: 10.3390/ijms17081302.
5
Antifungal activity of chitinase obtained from Paenibacillus ehimensis MA2012 against conidial of Collectotrichum gloeosporioides in vitro.从埃希氏类芽孢杆菌MA2012中获得的几丁质酶对体外培养的胶孢炭疽菌分生孢子的抗真菌活性。
Microb Pathog. 2016 Jul;96:10-4. doi: 10.1016/j.micpath.2016.04.016. Epub 2016 Apr 28.
6
Biocontrol activity of Paenibacillus polymyxa AC-1 against Pseudomonas syringae and its interaction with Arabidopsis thaliana.多粘芽孢杆菌AC-1对丁香假单胞菌的生防活性及其与拟南芥的相互作用。
Microbiol Res. 2016 Apr;185:13-21. doi: 10.1016/j.micres.2016.01.004. Epub 2016 Jan 22.
7
Production and Characterization of Antioxidant Properties of Exopolysaccharide(s) from Peanibacillus mucilaginosus TKU032.胶质芽孢杆菌TKU032胞外多糖抗氧化特性的产生与表征
Mar Drugs. 2016 Feb 19;14(2):40. doi: 10.3390/md14020040.
8
Chitinolytic Bacteria-Assisted Conversion of Squid Pen and Its Effect on Dyes and Pigments Adsorption.几丁质分解细菌辅助的鱿鱼骨转化及其对染料和色素吸附的影响
Mar Drugs. 2015 Jul 23;13(8):4576-93. doi: 10.3390/md13084576.
9
Recent advances in exopolysaccharides from Paenibacillus spp.: production, isolation, structure, and bioactivities.芽孢杆菌属胞外多糖的最新研究进展：生产、分离、结构及生物活性
Mar Drugs. 2015 Apr 1;13(4):1847-63. doi: 10.3390/md13041847.
10
Production and purification of a fungal chitosanase and chitooligomers from Penicillium janthinellum D4 and discovery of the enzyme activators.从青霉 D4 中生产和纯化真菌壳聚糖酶和壳寡糖，并发现该酶的激活剂。
Carbohydr Polym. 2014 Aug 8;108:331-7. doi: 10.1016/j.carbpol.2014.02.053. Epub 2014 Feb 24.