Department of Chemistry, ‡Macromolecular Science and Engineering, and §Department of Biomedical Engineering, University of Michigan , Ann Arbor, Michigan 48109, United States.
ACS Nano. 2017 Nov 28;11(11):10665-10671. doi: 10.1021/acsnano.7b06826. Epub 2017 Nov 7.
Collagen is the primary protein component in mammalian connective tissues. Over the last 20 years, evidence has mounted that collagen matrices exhibit substantial heterogeneity in their hierarchical structures and that this heterogeneity plays important roles in both structure and function. Herein, an overview of studies addressing the nanoscale compositional and structural heterogeneity is provided and connected to work exploring the mechanical implications for a number of tissues.
胶原蛋白是哺乳动物结缔组织中的主要蛋白质成分。在过去的 20 年中，越来越多的证据表明胶原蛋白基质在其层次结构中表现出显著的异质性，这种异质性在结构和功能中都起着重要作用。本文综述了研究胶原蛋白纳米级组成和结构异质性的研究，并将其与研究一些组织的力学影响的工作联系起来。
