Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY 10065, USA.
Curr Biol. 2017 Nov 6;27(21):R1158-R1160. doi: 10.1016/j.cub.2017.09.023.
Single-molecule force spectroscopy and modeling have revealed that the adhesion molecule vinculin and F-actin form a catch bond that is dependent on the direction of forces along the actin filament. This may underlie the mechanisms by which cells sense directional physical cues.
单分子力谱学和建模研究表明，黏着斑蛋白 vinculin 和 F-肌动蛋白形成了一种依赖于肌动蛋白丝上力的方向的捕获键。这可能是细胞感知定向物理线索的机制基础。
