Modenato C, Draganski B
LREN, University of Lausanne, Dept. of clinical neurosciences, CHUV, Lausanne Switzerland.
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Schizophr Res Cogn. 2015 Jun 20;2(2):89-92. doi: 10.1016/j.scog.2015.05.001. eCollection 2015 Jun.
Despite major progress in diagnostic accuracy and symptomatic treatment of mental disorders, there is an ongoing debate about their classification aiming to follow current advances in neurobiology. The main goal of this review is to provide a comprehensive summary of the put forward schizotypy concept that follows the needs for objective assessment of schizophrenia-like personality traits in the general population. We focus on major achievements in the field from the perspective of magnetic resonance imaging-based computational anatomy of the brain. Particular interest is devoted to overlapping brain structure findings in schizotypy and schizophrenia to promote a dimensional view on schizophrenia as extension of phenotype traits in the non-clinical general population.
尽管在精神障碍的诊断准确性和症状治疗方面取得了重大进展，但关于其分类的争论仍在继续，目的是跟上神经生物学的当前进展。本综述的主要目标是全面总结所提出的分裂型特质概念，该概念符合对普通人群中类似精神分裂症人格特质进行客观评估的需求。我们从基于磁共振成像的脑计算解剖学角度关注该领域的主要成就。特别关注分裂型特质和精神分裂症中重叠的脑结构发现，以促进将精神分裂症视为非临床普通人群表型特征延伸的维度观点。
