Hallberg L, Brune M, Rossander L
Department of Medicine II, University of Göteborg, Sweden.
Am J Clin Nutr. 1989 Jan;49(1):140-4. doi: 10.1093/ajcn/49.1.140.
The dose-dependent inhibitory effect of sodium phytate on iron absorption was studied in man by serving wheat rolls containing no phytates and rolls to which various amounts (seven dose levels between 2 and 250 mg expressed as phytate phosphorus) were added just before serving. Fe in the two kinds of rolls was labeled with two radioisotopes of Fe (55Fe, 59Fe) and the rolls were served on alternate days. The inhibition of Fe absorption was strongly related to the amount of phytate added; 2 mg inhibited absorption by 18%, (p less than 0.001), 25 mg by 64% (p less than 0.001), and 250 mg by 82% (p less than 0.001). The addition of ascorbic acid significantly counteracted the inhibition whereas the corresponding effect of meat was less well defined and only seen at the highest phytate level. The marked inhibition of Fe absorption by phytates and the significant counteracting effect of ascorbic acid have wide nutritional implications.
通过向人体受试者提供不含植酸盐的小麦面包卷以及在食用前添加了不同量（以植酸磷计，2至250毫克之间的七个剂量水平）植酸盐的面包卷，研究了植酸钠对铁吸收的剂量依赖性抑制作用。两种面包卷中的铁都用两种铁的放射性同位素（55Fe、59Fe）进行标记，两种面包卷隔天交替提供。铁吸收的抑制作用与添加的植酸盐量密切相关；2毫克植酸盐可使铁吸收抑制18%（p<0.001），25毫克可抑制64%（p<0.001），250毫克可抑制82%（p<0.001）。添加抗坏血酸可显著抵消这种抑制作用，而肉类的相应作用则不太明确，仅在最高植酸盐水平时才可见。植酸盐对铁吸收的显著抑制作用以及抗坏血酸的显著抵消作用具有广泛的营养意义。
