Lee Yi-Chen, Cheng Chun-Wen, Lee Huei-Jane, Chu Huei-Chuien
1 Department of Nutrition Therapy, E-DA Hospital , Kaohsiung City, Taiwan .
2 Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University , Taichung City, Taiwan .
J Med Food. 2017 Nov;20(11):1113-1120. doi: 10.1089/jmf.2017.3951.
Indomethacin is a nonsteroid anti-inflammatory drug (NSAID) that is used to alleviate pain and inflammation in clinical medicine. Previous studies indicated that NSAIDs can cause gastrointestinal mucosal complications, and it is associated with mucosal lipid peroxidation and oxidative damage. Based on the evidences, decreasing oxidative stress may be an ideal therapeutic strategy for preventing gastrointestinal ulcer. Apple (Rosaceae Malus sp.) is one of the most commonly consumed fruits worldwide. The abundant polyphenolic constituents have received increasing attention for decades. In both in vivo and in vitro studies, the reports showed that apple polyphenol (AP) seems to provide an indirect antioxidant protection by activating cellular antioxidant enzymes to defend against oxidative stress. To address this issue and develop AP into a healthy improvement supplement, we studied the effect and potential mechanisms of AP in indomethacin-treated animal. The results showed AP can decelerate the gastric lesion, significantly suppress lipid peroxidation, increase the level of glutathione and the activity of catalase, and regulate the MAPK signaling proteins. These findings imply that AP protects the gastric mucosa from indomethacin-caused lesions and the protection is at least partially attributable to its antioxidative properties. This alternative medical function of AP may be a safe and effective intervention for preventing indomethacin-induced gastric complications.
吲哚美辛是一种非甾体抗炎药（NSAID），在临床医学中用于减轻疼痛和炎症。先前的研究表明，NSAIDs可引起胃肠道黏膜并发症，且与黏膜脂质过氧化和氧化损伤有关。基于这些证据，降低氧化应激可能是预防胃溃疡的理想治疗策略。苹果（蔷薇科苹果属）是全球最常食用的水果之一。几十年来，其丰富的多酚成分越来越受到关注。在体内和体外研究中，报告显示苹果多酚（AP）似乎通过激活细胞抗氧化酶来提供间接的抗氧化保护，以抵御氧化应激。为了解决这个问题并将AP开发成一种有益健康的补充剂，我们研究了AP对吲哚美辛处理动物的影响及其潜在机制。结果表明，AP可减缓胃部损伤，显著抑制脂质过氧化，提高谷胱甘肽水平和过氧化氢酶活性，并调节丝裂原活化蛋白激酶（MAPK）信号蛋白。这些发现表明，AP可保护胃黏膜免受吲哚美辛引起的损伤，且这种保护至少部分归因于其抗氧化特性。AP的这种替代医学功能可能是预防吲哚美辛诱导的胃部并发症的一种安全有效的干预措施。
