Gastroprotective effects of both aqueous and ethanolic extracts of leaves against indomethacin-induced gastric ulcer in rats.

OBJECTIVES

Regarding gastroprotective effects, we investigated the protective effects of extracts on reducing gastric ulcer induced by indomethacin.

MATERIALS AND METHODS

Rats received aqueous and ethanolic extracts of (50, 100, and 200 mg/kg), zileuton (100 mg/kg), montelukast (10 mg/kg), or 1% Tween 80 in presence or absence of indomethacin (100 mg/kg).

RESULTS

Indomethacin produced stomach ulcer and increased neutrophils percentage and MDA level compared with the control group (0.001). Co-administration of indomethacin and zileuton, montelukast and ethanolic (200 mg/kg) (0.001), aqueous extract (200 mg/kg) (0.05) reduced ulcer compared with the indomethacin group (0.001). Ethanolic extracts (100 and 200 mg/kg) and aqueous extract (200 mg/kg) reduced the MDA level (0.001). Ethanolic (50, 100, and 200 mg/kg) and aqueous extracts (200 mg/kg) significantly decreased neutrophils percentage compared with the indomethacin group (0.001).

CONCLUSION

Aqueous and particularly ethanolic extracts of have protective effects on indomethacin-induced gastric ulcers.