Kocak Nagihan Durmus, Gungor Sinem, Akturk Ulku Aka, Yalcinsoy Murat, Kavas Murat, Oztas Selahattin, Akkaya Mevhibe Esen, Aksoy Emine, Agca Meltem Coban, Duman Dildar, Karakurt Zuhal
Pulmonary Diseases, University of Health Sciences, Süreyyapaşa Chest Diseases and Thoracic Surgery Education and Research Hospital, İstanbul, Turkey.
Eurasian J Med. 2017 Oct;49(3):161-166. doi: 10.5152/eurasianjmed.2017.17181.
While the incidence of sarcoidosis peaks between 20 and 39 years, it is comparatively low in elderly subjects. We sought to determine whether there are age-dependent differences in the demographic and laboratory characteristics of patients with sarcoidosis.
We retrospectively collected information from our database using the International Classification of Disease (ICD) diagnostic code D86 between 2008 and 2014. Patients were divided into three groups: 20-39 years old (Group 1), 40-59 years old (Group 2), and 60-80 years old (Group 3).
A total of 3988 patients with code of D86 were included in the study. After the exclusion of non-eligible patients, the number of cases in Groups 1, 2, and 3 were 276, 641, and 352, respectively. The groups were compared according to demographic characteristics, ICD diagnostic codes, and laboratory parameters. The ratio of female patients was significantly higher in Group 3 than in Groups 1 and 2 (p=0.000). There was no difference in diagnostic codes of the ICD subgroups between groups (p=0.19). While the level of blood-urea nitrogen was significantly higher in Group 3 patients than in other groups (p=0.000), serum angiotensin-converting enzyme (ACE) values were found to be significantly low in Group 3 (p=0.010). The mean ACE values did not differ between females and males (50.8±39.3 and 59.1±45.5 mg/dL, respectively) (p=0.18).
The majority of patients with sarcoidosis were female in all age groups and pulmonary sarcoidosis was the most common presentation of the disease. Elderly patients (≥60 years) with sarcoidosis had lower serum ACE levels than younger patients.
结节病的发病率在20至39岁达到峰值，而在老年患者中相对较低。我们试图确定结节病患者的人口统计学和实验室特征是否存在年龄依赖性差异。
我们使用国际疾病分类（ICD）诊断代码D86，从2008年至2014年的数据库中回顾性收集信息。患者分为三组：20至39岁（第1组）、40至59岁（第2组）和60至80岁（第3组）。
本研究共纳入3988例诊断代码为D86的患者。排除不符合条件的患者后，第1组、第2组和第3组的病例数分别为276例、641例和352例。根据人口统计学特征、ICD诊断代码和实验室参数对各组进行比较。第3组女性患者的比例显著高于第1组和第2组（p = 0.000）。各组间ICD亚组的诊断代码无差异（p = 0.19）。第3组患者的血尿素氮水平显著高于其他组（p = 0.000），而第3组的血清血管紧张素转换酶（ACE）值显著较低（p = 0.010）。女性和男性的平均ACE值无差异（分别为50.8±39.3和59.1±45.5 mg/dL）（p = 0.18）。
所有年龄组的结节病患者中女性居多，肺部结节病是该疾病最常见的表现形式。结节病老年患者（≥60岁）的血清ACE水平低于年轻患者。
