Ni Wen-Juan, Leng Xiao-Min
Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Henan 453100, People's Republic of China.
Biochem Biophys Rep. 2015 Oct 28;4:337-341. doi: 10.1016/j.bbrep.2015.10.011. eCollection 2015 Dec.
More and more evidences suggested that the flow of genetic information can be spatially and temporally regulated by non-coding RNAs (ncRNAs), such as microRNAs (miRNAs). Although biogenesis and function of miRNAs have been well detailed, elucidation of the dynamic interplays between miRNAs and mRNAs have just begun. Here, we highlighted that the miRNA-mRNA interactions which could take place in different cellular locations. During dynamic interactions, miRNA binding sites included not only 3'UTRs, but also 5'UTRs and CDSs. Under different physiological or pathological conditions, miRNAs could switch from translational inhibition to activation. Dynamic miRNA-mRNA paradigms which suggested a novel tip of the iceberg beneath the gene regulation network will provide clues for function studies of other ncRNAs.
越来越多的证据表明，遗传信息的流动可受到非编码RNA（ncRNA），如微小RNA（miRNA）在空间和时间上的调控。尽管miRNA的生物合成和功能已得到详细阐述，但对miRNA与mRNA之间动态相互作用的阐明才刚刚开始。在此，我们强调miRNA与mRNA的相互作用可发生在不同的细胞位置。在动态相互作用过程中，miRNA结合位点不仅包括3'非翻译区（3'UTR），还包括5'非翻译区（5'UTR）和编码序列（CDS）。在不同的生理或病理条件下，miRNA可从翻译抑制转变为激活。动态的miRNA - mRNA模式揭示了基因调控网络下新的冰山一角，将为其他ncRNA的功能研究提供线索。
