Cellular and Molecular Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Graduate Physiology Program, North Carolina State University, Raleigh, NC, USA.
Top Curr Chem (Cham). 2017 Nov 9;375(6):88. doi: 10.1007/s41061-017-0176-x.
Selenium binds some enzymes such as glutathione peroxidase and thioredoxin reductase, which may be activated in biological infections and oxidative stress. Chemical and physical methods for synthesizing nanoparticles, apart from being expensive, have their own particular risks. However, nanoparticle synthesis through green chemistry is a safe procedure that different biological sources such as bacteria, fungi, yeasts, algae and plants can be the catalyst bed for processing. Synthesis of selenium nanoparticles (SeNPs) by macro/microorganisms causes variation in morphology and shape of the particles is due to diversity of reduction enzymes in organisms. Reducing enzymes of microorganisms by changing the status of redox convert metal ions (Se) to SeNPs without charge (Se). Biological activity of SeNPs includes their protective role against DNA oxidation. Because of the biological and industrial properties, SeNPs have wide applications in the fields of medicine, microelectronic, agriculture and animal husbandry. SeNPs can show strong antimicrobial effects on the growth and proliferation of microorganisms in a dose-dependent manner. The objective of this review is to consider SeNPs applications to various organisms.
硒结合一些酶，如谷胱甘肽过氧化物酶和硫氧还蛋白还原酶，这些酶可能在生物感染和氧化应激中被激活。化学和物理方法合成纳米粒子，除了昂贵之外，还有其自身的特定风险。然而，通过绿色化学合成纳米粒子是一种安全的方法，不同的生物来源，如细菌、真菌、酵母、藻类和植物，可以作为加工的催化剂床。通过大型/微生物合成硒纳米粒子 (SeNPs) 会导致颗粒的形态和形状发生变化，这是由于生物体中还原酶的多样性所致。微生物的还原酶通过改变氧化还原状态将金属离子 (Se) 转化为不带电荷的 SeNPs (Se)。SeNPs 的生物活性包括其防止 DNA 氧化的保护作用。由于具有生物和工业特性，SeNPs 在医学、微电子、农业和畜牧业等领域有广泛的应用。SeNPs 可以在剂量依赖的方式下对微生物的生长和增殖表现出强烈的抗菌作用。本综述的目的是考虑将 SeNPs 应用于各种生物体。
