Bellan Mattia, Sainaghi Pier Paolo, Pirisi Mario
Department of Translational Medicine, Università del Piemonte Orientale UPO, via Solaroli 17, 28100, Novara, Italy.
Immunorheumatology Unit, Internal Medicine Division, AOU Maggiore della Carità, Novara, Italy.
Adv Exp Med Biol. 2017;996:155-168. doi: 10.1007/978-3-319-56017-5_13.
Vitamin D is a fat soluble hormone, with a well described role in bone health and calcium/phosphate metabolism. Recent evidences have related vitamin D to other physiological functions and pathological conditions. Specifically, vitamin D has widely proven activities on immune system and evidences suggest that it may be implicated in the pathogenesis of rheumatoid arthritis (RA). The relationship between vitamin D and RA is complex, also because a deficitary vitamin D status, which is very common in RA patients, can contribute to the increased risk of osteoporosis typical of RA. In this chapter, will be described and discussed the main aspects of the relationship between RA and vitamin D.
维生素D是一种脂溶性激素，在骨骼健康和钙/磷代谢方面的作用已广为人知。最近的证据表明维生素D与其他生理功能和病理状况有关。具体而言，维生素D在免疫系统方面具有广泛证实的活性，并且有证据表明它可能与类风湿性关节炎（RA）的发病机制有关。维生素D与RA之间的关系很复杂，这还因为维生素D缺乏状态在RA患者中非常常见，而这种状态会导致RA患者典型的骨质疏松风险增加。在本章中，将描述和讨论RA与维生素D之间关系的主要方面。
