从（Turcz）Baill. 的茎和叶中分离、结构鉴定三种新的三萜类化合物。
Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of (Turcz) Baill.
机构信息
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
出版信息
Molecules. 2018 Jul 4;23(7):1624. doi: 10.3390/molecules23071624.
(Turcz) Baill. is sufficiently well known as a medicinal plant worldwide, which modern research shows has many pharmacological activities such as hepatoprotective, anti-inflammatory effect, potent anti-HIV-1 activity, anti-tumor effect, and activity on the central nervous system. With considerable chemical investigation, three new triterpenoids (⁻), together with four known triterpenoids were isolated from the (Turcz) Baill. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analyses, single-crystal X-ray diffraction and high-resolution mass spectroscopy, which were identified as Schisanlactone I (), Schinalactone D, (), Schisanlactone J, () Kadsuphilactone B (), Schisanlactone C (), Schisphendilactone B (), and Schinchinenlactone A (). The cytotoxicity of those compounds (⁻) was tested against Hep-G2 cell lines, but no apparent antitumor activity was observed at 50 µg/mL using MTT method.
（Turcz）Baill. 作为一种药用植物在全球范围内已广为人知，现代研究表明它具有多种药理学活性，如肝保护、抗炎作用、抗 HIV-1 的活性、抗肿瘤作用以及对中枢神经系统的作用。通过相当多的化学研究，从（Turcz）Baill. 中分离得到了三个新的三萜类化合物（⁻），以及四个已知的三萜类化合物。它们的结构通过 1D- 和 2D-NMR 光谱分析、单晶 X 射线衍射和高分辨率质谱确定，分别鉴定为 Schisanlactone I ()、Schinalactone D、()、Schisanlactone J ()、Kadsuphilactone B ()、Schisanlactone C ()、Schisphendilactone B () 和 Schinchinenlactone A ()。用 MTT 法测定这些化合物（⁻）对 Hep-G2 细胞系的细胞毒性，但在 50 µg/mL 时没有观察到明显的抗肿瘤活性。
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