Song Qiu-Yan, Gao Kun, Nan Zhi-Biao
a State Key Laboratory of Grassland Agro-ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University , Lanzhou 730020 , China.
b State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000 , China.
J Asian Nat Prod Res. 2016;18(2):189-94. doi: 10.1080/10286020.2015.1056165. Epub 2015 Aug 27.
A new highly oxygenated triterpenoid, schinchinenlactone D (1), and three known compounds (2-4) were isolated from the roots of Schisandra chinensis. Their structures were determined by combining the spectroscopic analysis with the theoretical computations. The anti-inflammatory activities of compounds 1-4 were evaluated, and compound 3 exhibits the most significant activity in the inhibition of NO production with an IC50 value of 10.6 μM.
从五味子根部分离出一种新的高氧化三萜类化合物——华中五味子内酯D（1）以及三种已知化合物（2 - 4）。通过光谱分析与理论计算相结合的方法确定了它们的结构。对化合物1 - 4的抗炎活性进行了评估，化合物3在抑制NO生成方面表现出最显著的活性，IC50值为10.6 μM。
