柳叶五味子叶和茎的化学成分

Chemical constituents from the leaves and stems of Schisandra lancifolia.

作者信息

Xiao Wei-Lie, Yang Liu-Meng, Zhang Hai-Bo, Xue Yong-Bo, Yang Guang-Yu, Pu Jian-Xin, Wang Rui-Rui, Zheng Yong-Tang, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences.

出版信息

Chem Pharm Bull (Tokyo). 2010 Jun;58(6):852-5. doi: 10.1248/cpb.58.852.

DOI:10.1248/cpb.58.852

PMID:20522999

Abstract

A new nortriterpenoid, 20-hydroxymicrandilactone D (1) and a novel lignan glycoside, lancilignanside A (2) were isolated from leaves and stems of Schisandra lancifolia, together with three known nortriterpenoids (3-5) and nine known phenolics (6-14). The structures of new compounds 1 and 2 were determined by detailed analysis of their 1D and 2D NMR spectra, and chemical evidences. In addition, compounds 1-2, 6-7, and 9-11 showed anti-human immunodeficiency virus (HIV)-1 activities with 50% effective concentration (EC(50)) in the range of 3.0-99.0 microg/ml. Compound 12 was not bioactive in this assay with EC(50) more than 200 microg/ml.

摘要

从柳叶五味子的叶和茎中分离得到一个新的三萜类化合物，20-羟基南五味子内酯D（1）和一个新的木脂糖苷，南五味子木脂苷A（2），同时还得到三个已知的三萜类化合物（3-5）和九个已知的酚类化合物（6-14）。通过对化合物1和2的一维和二维核磁共振谱的详细分析以及化学证据确定了它们的结构。此外，化合物1-2、6-7和9-11显示出抗人类免疫缺陷病毒（HIV）-1活性，其半数有效浓度（EC50）在3.0-99.0μg/ml范围内。化合物12在该试验中无生物活性，其EC50大于200μg/ml。