Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan, 030006, China.
State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China.
Sci China Life Sci. 2018 May;61(5):523-533. doi: 10.1007/s11427-017-9169-6. Epub 2017 Nov 8.
AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that plays a key role in energetic metabolism regulation. Metabolic changes in immune cells, such as dendritic cell (DC), macrophages, neutrophils and lymphocytes that participate in the signal directed programs that promote or inhibit immune mediated diseases, including cancer, atherosclerosis and inflammatory diseases. Multiple pathogenic mechanisms are involved in the initiation and progression of disease, and many pathways have been uncovered. The mechanistic overlap in the metabolic changes and inflammation could indicate that some of the targets they have are in common, whereas AMPK could be useful in treatment of both disorders. The insight into identification of AMPK responsible for specific immune regulation, anti-inflammatory actions and understanding of the underlying molecular mechanism will promote the generation of novel AMPK activators, and provide novel therapy strategy.
腺苷酸活化蛋白激酶（AMPK）是细胞能量状态的传感器，在能量代谢调节中起着关键作用。参与信号定向程序的免疫细胞（如树突状细胞（DC）、巨噬细胞、中性粒细胞和淋巴细胞）的代谢变化，促进或抑制包括癌症、动脉粥样硬化和炎症性疾病在内的免疫介导疾病。疾病的发生和发展涉及多种发病机制，许多途径已经被揭示。代谢变化和炎症之间的机制重叠表明，它们的一些靶点是共同的，而 AMPK 可能对这两种疾病的治疗都有用。对负责特定免疫调节、抗炎作用以及理解潜在分子机制的 AMPK 的深入了解将促进新型 AMPK 激活剂的产生，并提供新的治疗策略。
