Liu Jingtang, Gu Binbin, Yang Lianjuan, Yang Fan, Lin Houwen
Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
The Fungal Reference Laboratory of Shanghai Dermatology Hospital, Shanghai, China.
Front Chem. 2018 Jun 14;6:226. doi: 10.3389/fchem.2018.00226. eCollection 2018.
Three new cyclic peptides including a cyclic tetrapeptide (), an aspochracin-type cyclic tripeptide sclerotiotide L () and a diketopiperazine dimer (), have been isolated from the ethyl acetate extract of a marine sponge-derived fungus . The structures of all compounds were unambiguously elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopic data, MS/MS experiments and chemical methods. Compounds and showed anti-inflammatory activity against IL-10 expression of the LPS-induced THP-1 cells with inhibitory rates of 84.3 and 78.1% respectively at concentration of 10 μM.
从一种海洋海绵来源真菌的乙酸乙酯提取物中分离出三种新的环肽，包括一种环四肽（）、一种曲霉青霉素型环三肽硬皮菌素L（）和一种二酮哌嗪二聚体（）。所有化合物的结构均通过高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振光谱数据、串联质谱实验以及化学方法得到明确阐明。化合物和在浓度为10 μM时，对脂多糖诱导的THP - 1细胞的白细胞介素 - 10表达具有抗炎活性，抑制率分别为84.3%和78.1%。
