科威特呼吸道感染患者中的人类华盛顿大学多瘤病毒。
Human Washington University Polyomavirus in Patients with Respiratory Tract Infection in Kuwait.
出版信息
Med Princ Pract. 2017;26(6):542-546. doi: 10.1159/000485036. Epub 2017 Nov 7.
OBJECTIVE
To determine Washington University (WU) polyomavirus strains circulating among hospitalized patients with respiratory tract infections (RTI) in Kuwait.
MATERIALS AND METHODS
Samples from 459 hospitalized children and adult RTI patients were screened for respiratory viruses by polymerase chain reaction from April 2013 to April 2016. The VP2 gene from WU virus (WUV)-positive samples was sequenced and subjected to phylogenetic analysis.
RESULTS
Of the 459 hospitalized RTI patients, 18 (3.9%) patients were positive for WUV infection. WUV infection was common among children aged ≤11 years (9 patients, 50%). Among the 18 WUV-infected hospitalized patients, viral co-infection was detected in 9 patients (50%). The most common viruses associated with mixed infection were respiratory syncytial virus and human rhinovirus (2 patients, 11.1% each). Of the 18 WUV-infected patients, 4 were sequenced and subjected to phylogenetic analysis. The circulating strains belong to type Ia and IIIb.
CONCLUSION
This study enabled us to detect WUV among hospitalized RTI patients. Co-infection with other respiratory viruses was notable. Two circulating WUV genotypes (Ia and IIIb) were identified among hospitalized RTI patients in Kuwait.
目的
确定在科威特住院呼吸道感染（RTI）患者中流行的华盛顿大学（WU）多瘤病毒株。
材料和方法
2013 年 4 月至 2016 年 4 月，对 459 例住院儿童和成人 RTI 患者的样本进行呼吸道病毒聚合酶链反应检测。对 WU 病毒（WUV）阳性样本的 VP2 基因进行测序并进行系统发育分析。
结果
在 459 例住院 RTI 患者中，有 18 例（3.9%）患者 WUV 感染阳性。WU 病毒感染在≤11 岁的儿童中很常见（9 例，占 50%）。在 18 例 WUV 感染的住院患者中，有 9 例（50%）检测到病毒合并感染。最常见的与混合感染相关的病毒是呼吸道合胞病毒和人类鼻病毒（各 2 例，占 11.1%）。在 18 例 WUV 感染患者中，有 4 例进行了测序并进行了系统发育分析。流行株属于 I 型和 IIIb 型。
结论
本研究能够在住院 RTI 患者中检测到 WUV。与其他呼吸道病毒的合并感染很明显。在科威特住院 RTI 患者中发现了两种循环 WUV 基因型（I 型和 IIIb 型）。
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