Belkin Daniel A, Jeon Hana, Weiss Elliot, Brauer Jeremy A, Geronemus Roy G
Laser & Skin Surgery Center of New York, 317 East 34th Street, New York, New York, 10016.
Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, 10016.
Lasers Surg Med. 2018 Jan;50(1):56-60. doi: 10.1002/lsm.22757. Epub 2017 Nov 13.
Nevus of Ota represents congenital dermal melanocytosis in a trigeminal distribution, most commonly occurring in Asian individuals and other individuals with skin of color. Evidence suggests early treatment is beneficial. Multiple reports have shown efficacy and safety of Q-switched laser treatment in adults. There is little data on children and in non-Asian skin types. This series was done to demonstrate safe and effective use of Q-switched laser therapy in children of multiple skin types.
Retrospective case series.
This was a chart review of patients under 18 years old who presented to our practice from 2002 to 2015 with a clinical diagnosis of nevus of Ota who were treated with Q-switched lasers (694 and 1,064 nm). Patients were treated without the use of general anesthesia or sedation, and corneal shields were used in appropriate cases. Percentage of improvement as well as side effects were rated by five physicians independently. Improvement, when present, was rated in quartiles (1-25%, 26-50%, 51-75%, and 76-100% improvement).
Twenty-four children were included. The average age at the start of treatment was 3.9 years old (range of 3 months to 12.4 years), and patients had Fitzpatrick skin types IV through VI. The mean number of treatments was 9.3. Assessment revealed excellent response (76-100% improvement) in 70% of patients and good to excellent response (51-100% improvement) in 86%. Two patients (8%) had post-inflammatory hyperpigmentation, one of whom also had focal hypopigmentation.
Treatment of nevus of Ota with Q-switched lasers in children with skin of color, without general anesthesia or sedation, is safe and effective. Early intervention should be encouraged for better efficacy and to prevent psychosocial distress in later childhood and adulthood. Lasers Surg. Med. 50:56-60, 2018. © 2017 Wiley Periodicals, Inc.
太田痣是一种先天性真皮黑素细胞增多症，呈三叉神经分布，最常见于亚洲人和其他有色人种个体。有证据表明早期治疗有益。多项报告显示调Q激光治疗对成人有效且安全。关于儿童及非亚洲皮肤类型的数据较少。本系列研究旨在证明调Q激光疗法在多种皮肤类型儿童中的安全有效应用。
回顾性病例系列。
对2002年至2015年到我们诊所就诊、临床诊断为太田痣且接受调Q激光（694和1064纳米）治疗的18岁以下患者进行病历回顾。患者治疗时未使用全身麻醉或镇静，适当情况下使用角膜保护罩。由五位医生独立评定改善百分比及副作用。如有改善，按四分位数评定（改善1%-25%、26%-50%、51%-75%和76%-100%）。
纳入24名儿童。治疗开始时的平均年龄为3.9岁（范围为3个月至12.4岁），患者的皮肤类型为菲茨帕特里克IV型至VI型。平均治疗次数为9.3次。评估显示70%的患者有极佳反应（改善76%-100%），86%的患者有良好至极佳反应（改善51%-100%）。两名患者（8%）出现炎症后色素沉着，其中一名还伴有局部色素减退。
在有色人种儿童中，不使用全身麻醉或镇静，用调Q激光治疗太田痣是安全有效的。应鼓励早期干预以获得更好疗效，并防止儿童后期及成年期出现心理社会困扰。《激光外科与医学》50:56 - 60, 2018。© 2017威利期刊公司
