川崎病的诊断
Diagnosis of Kawasaki disease.
作者信息
Singh Surjit, Jindal Ankur Kumar, Pilania Rakesh Kumar
机构信息
Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post-Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
出版信息
Int J Rheum Dis. 2018 Jan;21(1):36-44. doi: 10.1111/1756-185X.13224. Epub 2017 Nov 13.
Abstract
Kawasaki disease (KD) is a medium vessel vasculitis with predilection for coronary arteries. Due to lack of a reliable confirmatory laboratory test, the diagnosis of KD is based on a constellation of clinical findings that appear in a typical temporal sequence. These diagnostic criteria have been modified from time to time and the most recent guidelines have been proposed by the American Heart Association (AHA) in 2017. However, several children may have incomplete or atypical forms of KD and the diagnosis can often be difficult, especially in infants and young children. In this review, we have detailed the steps involved in arriving at a diagnosis of KD and also highlight the important role of echocardiography in diagnosis and management of children with KD.
摘要
川崎病（KD）是一种主要累及中等血管、好发于冠状动脉的血管炎。由于缺乏可靠的确诊实验室检查，KD的诊断基于一系列按典型时间顺序出现的临床症状。这些诊断标准不时进行修订，美国心脏协会（AHA）于2017年提出了最新指南。然而，一些儿童可能患有不完全或非典型形式的KD，诊断往往很困难，尤其是在婴幼儿中。在这篇综述中，我们详细阐述了KD诊断所涉及的步骤，并强调了超声心动图在KD患儿诊断和管理中的重要作用。
相似文献
1
Diagnosis of Kawasaki disease.川崎病的诊断
Int J Rheum Dis. 2018 Jan;21(1):36-44. doi: 10.1111/1756-185X.13224. Epub 2017 Nov 13.
2
Predicting Coronary Artery Aneurysms in Kawasaki Disease at a North American Center: An Assessment of Baseline Scores.北美某中心对川崎病患者冠状动脉瘤的预测：基线评分评估
J Am Heart Assoc. 2017 May 31;6(6):e005378. doi: 10.1161/JAHA.116.005378.
3
Value of serial echocardiography in diagnosing Kawasaki's disease.系列超声心动图在诊断川崎病中的价值。
Eur J Pediatr. 2021 Feb;180(2):387-395. doi: 10.1007/s00431-020-03752-y. Epub 2020 Sep 21.
4
N-terminal pro-B-type natriuretic peptide diagnostic algorithm versus American Heart Association algorithm for Kawasaki disease.用于川崎病的N末端前B型利钠肽诊断算法与美国心脏协会算法的比较
Pediatr Int. 2017 Mar;59(3):265-270. doi: 10.1111/ped.13154. Epub 2016 Dec 2.
5
Examining the Utility of Coronary Artery Lack of Tapering and Perivascular Brightness in Incomplete Kawasaki Disease.探讨冠状动脉无逐渐变细及血管周围亮度在不完全川崎病中的应用价值。
Pediatr Cardiol. 2019 Jan;40(1):147-153. doi: 10.1007/s00246-018-1971-z. Epub 2018 Sep 8.
6
Risk factors and implications of progressive coronary dilatation in children with Kawasaki disease.川崎病患儿冠状动脉进行性扩张的危险因素及影响
BMC Pediatr. 2017 Jun 6;17(1):139. doi: 10.1186/s12887-017-0895-8.
7
Kawasaki disease: characteristics, diagnosis, and unusual presentations.川崎病：特征、诊断和不常见表现。
Expert Rev Clin Immunol. 2019 Oct;15(10):1089-1104. doi: 10.1080/1744666X.2019.1659726. Epub 2019 Oct 1.
8
Coronary artery dilation in acute Kawasaki disease and acute illnesses associated with Fever.川崎病急性期冠状动脉扩张和与发热相关的急性疾病。
Pediatr Infect Dis J. 2012 Sep;31(9):924-6. doi: 10.1097/INF.0b013e31826252b3.
9
The role of echocardiography in Kawasaki disease.超声心动图在川崎病中的作用。
Int J Rheum Dis. 2018 Jan;21(1):50-55. doi: 10.1111/1756-185X.13216. Epub 2017 Nov 19.
10
Potential link between SARS-CoV-2 and Kawasaki disease: importance of dentists for the diagnosis.SARS-CoV-2 与川崎病之间的潜在联系：牙医在诊断中的重要性。
Braz Oral Res. 2021 Mar 12;35:e047. doi: 10.1590/1807-3107bor-2021.vol35.0047. eCollection 2021.
引用本文的文献
1
Intestinal Dysbiosis and Immune Activation in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: A Comparative Review of Mechanisms and Clinical Manifestations.川崎病和儿童多系统炎症综合征中的肠道菌群失调与免疫激活：机制与临床表现的比较综述
Biomedicines. 2025 Aug 10;13(8):1953. doi: 10.3390/biomedicines13081953.
2
Association Between Levels of N-Terminal Pro-brain Natriuretic Peptide and Coronary Artery Lesion in Patients with Kawasaki Disease: A Systematic Review and Meta-analysis.川崎病患者N末端脑钠肽前体水平与冠状动脉病变的关联：一项系统评价和荟萃分析
Arch Rheumatol. 2025 Jun 23;40(2):256-266. doi: 10.5152/ArchRheumatol.2025.11128.
3
Immunophenotype of Kawasaki Disease: Insights into Pathogenesis and Treatment Response.川崎病的免疫表型：对发病机制和治疗反应的见解
Life (Basel). 2025 Jun 25;15(7):1012. doi: 10.3390/life15071012.
4
Metabolomic Profiling for Predicting Coronary Artery Aneurysms and IVIG Resistance in Kawasaki Disease- An Exploratory Study.代谢组学分析预测川崎病冠状动脉瘤和静脉注射免疫球蛋白耐药性的探索性研究
J Cardiovasc Transl Res. 2025 Jul 18. doi: 10.1007/s12265-025-10648-5.
5
Integrative machine learning identifies robust inflammation-related diagnostic biomarkers and stratifies immune-heterogeneous subtypes in Kawasaki disease.整合机器学习可识别川崎病中与炎症相关的可靠诊断生物标志物，并对免疫异质性亚型进行分层。
Pediatr Rheumatol Online J. 2025 Jun 2;23(1):61. doi: 10.1186/s12969-025-01114-2.
6
Case report: Cervical suppurative lymphadenitis caused by burkholderia multivorans in a healthy child.病例报告：一名健康儿童由多食伯克霍尔德菌引起的颈部化脓性淋巴结炎。
BMC Infect Dis. 2025 May 8;25(1):678. doi: 10.1186/s12879-025-11033-y.
7
Exploring the role of exosomal and non-exosomal non-coding RNAs in Kawasaki disease: Implications for diagnosis and therapeutic strategies against coronary artery aneurysms.探索外泌体和非外泌体非编码RNA在川崎病中的作用：对冠状动脉瘤诊断和治疗策略的启示
Biochem Biophys Rep. 2025 Mar 6;42:101970. doi: 10.1016/j.bbrep.2025.101970. eCollection 2025 Jun.
8
Assessment of sleep problems in patients with Kawasaki disease: a survey-based study.川崎病患者睡眠问题的评估：一项基于调查的研究。
BMC Pediatr. 2025 Feb 4;25(1):96. doi: 10.1186/s12887-025-05418-w.
9
Identification of key ferroptosis‑related biomarkers in Kawasaki disease by clinical and experimental validation.通过临床和实验验证鉴定川崎病中关键的铁死亡相关生物标志物
Biomed Rep. 2024 Nov 19;22(1):16. doi: 10.3892/br.2024.1894. eCollection 2025 Jan.
10
Management of Coronary Artery Diseases in Systemic Vasculitides: Complications and Strategies.系统性血管炎相关冠状动脉疾病的管理：并发症与策略。
Medicina (Kaunas). 2024 Sep 25;60(10):1574. doi: 10.3390/medicina60101574.
本文引用的文献
1
Simultaneous development of Kawasaki disease following acute human adenovirus infection in monozygotic twins: A case report.单卵双胞胎急性人腺病毒感染后同时发生川崎病：一例报告
Pediatr Rheumatol Online J. 2017 May 16;15(1):39. doi: 10.1186/s12969-017-0169-x.
2
Reaction of the BCG Scar in the Acute Phase of Kawasaki Disease in Mexican Children.墨西哥儿童川崎病急性期卡介苗疤痕的反应
Pediatr Infect Dis J. 2017 Oct;36(10):e237-e241. doi: 10.1097/INF.0000000000001633.
3
High Risk of Coronary Artery Aneurysms in Infants Younger than 6 Months of Age with Kawasaki Disease.6个月以下患有川崎病的婴儿发生冠状动脉瘤的风险较高。
J Pediatr. 2017 Jun;185:112-116.e1. doi: 10.1016/j.jpeds.2017.03.025. Epub 2017 Apr 10.
4
Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association.川崎病的诊断、治疗和长期管理：美国心脏协会发布的一份面向医疗保健专业人员的科学声明。
Circulation. 2017 Apr 25;135(17):e927-e999. doi: 10.1161/CIR.0000000000000484. Epub 2017 Mar 29.
5
Comprehensive pathogen detection associated with four recurrent episodes of Kawasaki disease in a patient during a single year using next-generation sequencing.在一年内，使用二代测序技术对一名川崎病反复发病四次的患者进行综合病原体检测。
JMM Case Rep. 2016 Feb 1;3(1):e005019. doi: 10.1099/jmmcr.0.005019. eCollection 2016 Feb.
6
Afebrile Kawasaki disease with coronary artery dilatation.无发热性川崎病伴冠状动脉扩张。
Pediatr Int. 2017 Mar;59(3):375-377. doi: 10.1111/ped.13214.
7
Identification of candidate diagnostic serum biomarkers for Kawasaki disease using proteomic analysis.采用蛋白质组学分析鉴定川崎病的候选诊断血清标志物。
Sci Rep. 2017 Mar 6;7:43732. doi: 10.1038/srep43732.
8
Infantile Kawasaki disease presenting as acute meningoencephalitis.表现为急性脑膜脑炎的婴儿川崎病。
Int J Rheum Dis. 2017 Dec;20(12):2225-2226. doi: 10.1111/1756-185X.13014. Epub 2017 Feb 9.
9
Dengue Fever Triggering Kawasaki Disease.登革热引发川崎病。
Indian Pediatr. 2017 Jan 15;54(1):51-52. doi: 10.1007/s13312-017-0997-2.
10
Serum miR-92a-3p as a New Potential Biomarker for Diagnosis of Kawasaki Disease with Coronary Artery Lesions.血清miR-92a-3p作为诊断川崎病合并冠状动脉病变的新型潜在生物标志物。
J Cardiovasc Transl Res. 2017 Feb;10(1):1-8. doi: 10.1007/s12265-016-9717-x. Epub 2016 Dec 15.
Zotero 插件