a Laboratoire de Psychologie et Neurocognition , University of Grenoble , Grenoble , France.
b Developmental Imaging and Psychopathology Lab, Faculty of Medicine , University of Geneva , Geneva , Switzerland.
Clin Neuropsychol. 2018 Jul;32(5):981-992. doi: 10.1080/13854046.2017.1403652. Epub 2017 Nov 14.
22q11.2 deletion syndrome, also known as velo-cardio-facial syndrome (VCFS) is a genetic disorder caused by a microdeletion on chromosome 22q11.2 and characterized by marked impairment in visual attention and executive function. The present study examined if this cognitive deficit extends to prospective memory (the type of memory involved in remembering to perform actions in the future).
20 participants with 22q11.2DS aged between 6 and 14 were included in the study as well as 22 typically developing individuals (TDC) aged 6-12. To measure prospective memory, participants were asked to play a driving game (the Dresden Cruiser). This time-based prospective memory task required children to remember to refuel their car when the fuel level was low by pressing a refuel button while driving.
Participants with 22q11.2DS remembered less often to refuel the car. Furthermore, participants with 22q11.2DS checked the fuel gage significantly less often than the controls.
Participants with 22q11.2DS therefore demonstrate difficulties completing a time-based prospective memory task. This can be explained by a generally less frequent time checking behavior in comparison to TDC.
22q11.2 缺失综合征，也称为心脏血管面部综合征（VCFS），是一种由染色体 22q11.2 微缺失引起的遗传疾病，其特征是视觉注意力和执行功能明显受损。本研究探讨了这种认知缺陷是否会扩展到前瞻性记忆（涉及未来执行动作的记忆类型）。
本研究纳入了 20 名年龄在 6 至 14 岁的 22q11.2DS 患者，以及 22 名年龄在 6-12 岁的典型发育儿童（TDC）。为了测量前瞻性记忆，参与者被要求玩一个驾驶游戏（德累斯顿巡洋舰）。这个基于时间的前瞻性记忆任务要求孩子们在燃料水平低时通过在驾驶时按下加油按钮来记住给汽车加油。
22q11.2DS 组的参与者记起加油的次数较少。此外，与对照组相比，22q11.2DS 组的参与者检查燃料计的频率明显较低。
因此，22q11.2DS 组的参与者在完成基于时间的前瞻性记忆任务时存在困难。与 TDC 相比，这可以解释为他们的时间检查行为频率普遍较低。
