Miettinen T A, Tilvis R S, Kesäniemi Y A
Second Department of Medicine, University of Helsinki, Finland.
Metabolism. 1989 Feb;38(2):136-40. doi: 10.1016/0026-0495(89)90252-7.
Serum cholestanol was studied in relation to fecal cholestanol excretion and cholesterol metabolism in a random middle-aged population of 61 men. The serum concentrations of cholestanol ranged from 1.6 to 10.8 mumol/L and were positively correlated with those of serum total LDL and HDL cholesterol. In terms of millimole per mole of cholesterol, these correlations disappeared; inverse associations were found with VLDL cholesterol and triglyceride levels, the P/S ratio of dietary fat, and the amount of fecal plant sterols, but not with fecal cholestanol. The serum contents of cholestanol (1) were also closely positively associated with those of serum plant sterols (campesterol and sitosterol) and fractional cholesterol absorption, (2) were inversely related to the fecal excretion of neutral sterols and cholesterol synthesis which were measured either by the sterol balance technique or serum cholesterol precursor sterols (desmosterol and lathosterol), and (3) were unrelated to bile acid synthesis. Fecal cholestanol (mean = 12.5 mg/d) was (1) clearly higher than the dietary cholestanol intake (less than 2 mg/d), (2) unrelated to serum cholestanol, and (3) positively correlated with the intestinal cholesterol (dietary plus endogenous) flux as well as fecal plant sterols, neutral sterols, and bacterial products of cholesterol. The study emphasizes that, in normal men, high serum cholestanol levels reflect high efficiency of intestinal sterol absorption and low cholesterol synthesis. Thus, the changes in the serum contents of cholestanol are parallel with those of plant sterols and opposite to those of cholesterol precursor sterols.
在一个由61名男性组成的随机中年人群中，研究了血清胆甾烷醇与粪便胆甾烷醇排泄及胆固醇代谢的关系。胆甾烷醇的血清浓度范围为1.6至10.8μmol/L，与血清总低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇呈正相关。以每摩尔胆固醇中的毫摩尔数计算，这些相关性消失；发现与极低密度脂蛋白（VLDL）胆固醇、甘油三酯水平、膳食脂肪的P/S比值以及粪便植物甾醇量呈负相关，但与粪便胆甾烷醇无关。胆甾烷醇的血清含量：（1）也与血清植物甾醇（菜油甾醇和谷甾醇）及胆固醇吸收分数密切正相关；（2）与通过甾醇平衡技术或血清胆固醇前体甾醇（羊毛甾醇和粪甾醇）测定的中性甾醇粪便排泄及胆固醇合成呈负相关；（3）与胆汁酸合成无关。粪便胆甾烷醇（平均 = 12.5mg/d）：（1）明显高于膳食胆甾烷醇摄入量（低于2mg/d）；（2）与血清胆甾烷醇无关；（3）与肠道胆固醇（膳食加内源性）通量以及粪便植物甾醇、中性甾醇和胆固醇的细菌产物呈正相关。该研究强调，在正常男性中，高血清胆甾烷醇水平反映肠道甾醇吸收效率高和胆固醇合成低。因此，胆甾烷醇血清含量的变化与植物甾醇的变化平行，与胆固醇前体甾醇的变化相反。
