Cambridge Institute for Medical Research, Addenbrookes Hospital, University of Cambridge, Cambridge, UK.
Traffic. 2018 Feb;19(2):150-152. doi: 10.1111/tra.12542. Epub 2017 Dec 21.
The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this long-established theory. Here, the evidence for and against a role for the retromer CSC in CIMPR endosome-to-Golgi retrieval is examined in the light of the new data that the SNX-BAR dimer is actually responsible for CIMPR retrieval.
该 retromer 货物选择复合物（CSC）组成 Vps35，Vps29 和 Vps26 介导阳离子独立甘露糖 6-磷酸受体（CIMPR）的内体到高尔基体的回收。 还是它？ 最近公布的数据对这一长期确立的理论的有效性提出了质疑。 在这里，根据新的数据，SNX-BAR 二聚体实际上负责 CIMPR 回收，重新审视了 retromer CSC 在 CIMPR 内体到高尔基体回收中的作用的证据。
