非肌肉浸润性膀胱癌的分子全景。
Molecular Landscape of Non-Muscle Invasive Bladder Cancer.
机构信息
Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Scott Department of Urology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Cancer Cell. 2017 Nov 13;32(5):550-551. doi: 10.1016/j.ccell.2017.08.015.
PMID:29136502
Abstract
In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations.
摘要
在本期《癌细胞》中，赫斯特等人报告了一项非侵入性（Ta 期）膀胱癌的综合分析。两种基因组亚型通过染色体 9q 缺失来区分，导致 AKT/PI3K/mTOR 信号的增加。女性患者的肿瘤具有更高频率的 KDM6A 突变。
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