Morra Mostafa Ebraheem, Elshafay Abdelrahman, Kansakar Aswin Ratna, Mehyar Ghaleb Muhammad, Dang Nguyen Phan Hoang, Mattar Omar Mohamed, Iqtadar Somia, Mostafa Mostafa Reda, Hai Vu Ngoc, Vu Tran Le-Huy, Ghazy Ahmed Abdelmotaleb, Kaboub Fatima, Huy Nguyen Tien, Hirayama Kenji
Faculty of Medicine, Al-Azhar University Dirghayu Guru Hospital and Research Center, Chabahil, Kathmandu, Nepal Al-Essra Hospital, Amman, Jordan Pham Ngoc Thach University of Medicine Faculty of Medicine, Cairo University, Cairo Faculty of Medicine, King Edward Medical University, Lahore, Pakistan Faculty of Medicine, Tanta University, Tanta University of Medicine and Pharmacy, District 5 University of California, Los Angeles, California Department of Health Ministry, Kafr El-Zayat, Gharbeya, Egypt Faculty of Medicine, University of Mentouri Constantine, Constantine, Algeria Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam Department of Clinical Product Development Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Medicine (Baltimore). 2017 Nov;96(45):e8025. doi: 10.1097/MD.0000000000008025.
Persistent vomiting is mentioned as a symptom of a large variety of systemic disorders. It is commonly used interchangeably with chronic, recurrent, or intractable vomiting and widely used as a warning sign of severe illness in dengue infection. However, it has been poorly defined in the medical literature. Therefore, we aimed to systematically review a definition of persistent vomiting in the medical literature.
A systematic search was done through; PubMed, Google Scholar, Web of Science, Scopus, VHL, WHO-GHL, Grey Literature Report, POPLINE, and SIGLE for the last 10 years. Consensus on the definition was considered to be reached if at least 50% of studies described the same definition using the Delphi consensus technique.
Of 2362 abstracts reviewed, 15 studies were selected based on the inclusion criteria. Three studies used the same definition. Another 2 studies defined it as vomiting of all foods and fluid in 24 hours. Three studies defined persistent vomiting in the units of days or weeks. Four studies used the number of episodes: ≥2 episodes 15 minutes apart, >3 episodes in 12 hours, and >3 episodes within 24 hours.
No consensus for the definition was found among authors. This is a point of concern that needs to be addressed by further studies.
持续性呕吐被提及为多种全身性疾病的一种症状。它通常与慢性、复发性或难治性呕吐互换使用，并被广泛用作登革热感染中严重疾病的警示信号。然而，医学文献中对其定义并不明确。因此，我们旨在系统回顾医学文献中持续性呕吐的定义。
对过去10年通过PubMed、谷歌学术、科学网、Scopus、VHL、世界卫生组织全球卫生图书馆、灰色文献报告、POPLINE和SIGLE进行系统检索。如果至少50%的研究使用德尔菲共识技术描述了相同的定义，则认为达成了关于该定义的共识。
在审查的2362篇摘要中，根据纳入标准选择了15项研究。三项研究使用了相同的定义。另外两项研究将其定义为24小时内呕吐所有食物和液体。三项研究以天数或周数来定义持续性呕吐。四项研究使用发作次数：间隔15分钟≥2次发作、12小时内>3次发作以及24小时内>3次发作。
作者之间未就该定义达成共识。这是一个需要通过进一步研究来解决的关注点。
