Wu Chih-Jen, Chen Cheng-Yi, Lai Thung-S, Wu Pei-Chen, Chuang Chih-Kuang, Sun Fang-Ju, Liu Hsuan-Liang, Chen Han-Hsiang, Yeh Hung-I, Lin Chih-Sheng, Lin Cheng-Jui
Division of Nephrology, Department of Internal Medicine, Mackay Memorial Hospital, Mackay Medical College ,Taipei, Taiwan.
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Oncotarget. 2017 Jun 28;8(47):83030-83037. doi: 10.18632/oncotarget.18789. eCollection 2017 Oct 10.
Renal anemia is a common complication in patients with advanced chronic kidney disease. studies have shown that indoxyl sulfate decreases erythropoietin production. Whether this effect is seen remains unclear. Our goal was to explore the role of indoxyl sulfate in renal anemia. We found serum indoxyl sulfate levels are significantly and negatively associated with erythropoietin levels in human. A multiple stepwise linear regression analyses after adjustment for other independent parameters revealed that free indoxyl sulfate, and total indoxyl sulfate were significantly associated with erythropoietin levels. In animal studies, erythropoietin gene and protein expression were markedly inhibited in rats with chronic kidney disease; however, this effect was significantly reversed by lowering serum indoxyl sulfate with AST-120. Indoxyl sulfate may also inhibit erythropoietin expression in animal models with chronic kidney disease. These findings further support the role of indoxyl sulfate in the development of renal anemia.
肾性贫血是晚期慢性肾脏病患者常见的并发症。研究表明，硫酸吲哚酚会降低促红细胞生成素的产生。这种效应是否存在仍不清楚。我们的目标是探讨硫酸吲哚酚在肾性贫血中的作用。我们发现，人体血清硫酸吲哚酚水平与促红细胞生成素水平显著负相关。在对其他独立参数进行调整后进行的多步线性回归分析显示，游离硫酸吲哚酚和总硫酸吲哚酚与促红细胞生成素水平显著相关。在动物研究中，慢性肾脏病大鼠的促红细胞生成素基因和蛋白表达受到显著抑制；然而，通过使用AST-120降低血清硫酸吲哚酚水平，这种效应得到了显著逆转。硫酸吲哚酚在慢性肾脏病动物模型中也可能抑制促红细胞生成素的表达。这些发现进一步支持了硫酸吲哚酚在肾性贫血发生发展中的作用。
