Department of Nephrology, Affiliated Hospital of Hebei University, No. 212 Yuhuadonglu, Baoding, 071000, People's Republic of China.
College of Clinical Medicine, Hebei University, No. 342 Yuhua Road, Baoding, 071000, People's Republic of China.
Int Urol Nephrol. 2022 Nov;54(11):2881-2890. doi: 10.1007/s11255-022-03209-1. Epub 2022 Apr 29.
Indoxyl sulphate (IS) a representative uraemic toxin in the blood of patients with chronic kidney disease (CKD). Its accumulation may be closely related to CKD and the increasing morbidity and mortality of the disease's related complications. Timely and effective detection of the IS level and efficient clearance of IS may effectively prevent the progression of CKD and its related complications. Therefore, this article summarizes the research progress of IS related, including IS in CKD and its associated complications including chronic kidney disease, chronic kidney disease with cardiovascular disease, renal anemia, bone mineral metabolic disease and neuropsychiatric disorders, looking for IS accurate rapid detection methods, and explore the efficient treatment to reduce blood levels of indole phenol sulphate.
硫酸吲哚酚（IS）是慢性肾脏病（CKD）患者血液中的一种代表性尿毒症毒素。其蓄积可能与 CKD 及其相关并发症的发病率和死亡率增加密切相关。及时有效地检测 IS 水平并有效清除 IS 可能有效预防 CKD 及其相关并发症的进展。因此，本文总结了 IS 相关的研究进展，包括 IS 在 CKD 及其相关并发症中的作用，包括慢性肾脏病、合并心血管疾病的慢性肾脏病、肾性贫血、骨矿物质代谢疾病和神经精神障碍，寻找 IS 的准确快速检测方法，并探讨有效的治疗方法以降低血液中吲哚酚硫酸盐的水平。
