Bouaziz Walid, Kanagaratnam Lukshe, Vogel Thomas, Schmitt Elise, Dramé Moustapha, Kaltenbach Georges, Geny Bernard, Lang Pierre Olivier
1 Geriatric Department, Medical School, University Hospitals of Strasbourg , Strasbourg, France .
2 Department of Physiology and EA-3072, Medical School, Strasbourg University , Strasbourg, France .
Rejuvenation Res. 2018 Aug;21(4):341-349. doi: 10.1089/rej.2017.1988. Epub 2018 Jan 2.
Older adults undergo a progressive decline in cardiorespiratory fitness and functional capacity. This lower peak oxygen uptake (VO) level is associated with increased risk of frailty, dependency, loss of autonomy, and mortality from all causes. Regular physical activity and particularly aerobic training (AT) have been shown to contribute to better and healthy aging. We conducted a meta-analysis to measure the exact benefit of AT on VO in seniors aged 70 years or older. A comprehensive, systematic database search for articles was performed in Embase, Medline, PubMed Central, Science Direct, Scopus, and Web of Science using key words. Two reviewers independently assessed interventional studies for potential inclusion. Ten randomized controlled trials (RCTs) were included totaling 348 seniors aged 70 years or older. Across the trials, no high risk of bias was measured and all considered open-label arms for controls. With significant heterogeneity between the RCTs (all p < 0.001), pooled analyses were computed for VO. Not only was VO found significantly higher in the training group compared to controls (mean difference [MD] = 1.56; 95% confidence interval [CI]: 0.90-2.23) in pooled analysis of the 10 RCTs but also when the analysis was adjusted on the participants' health statuses. MD among healthy and unhealthy seniors were, respectively, 1.72 (95% CI: 0.34-3.10) and 1.47 (95% CI: 0.60-2.34). This meta-analysis confirms the AT-associated benefits on VO in healthy and unhealthy seniors.
老年人的心肺功能和身体机能会逐渐下降。这种较低的峰值摄氧量（VO）水平与虚弱、依赖、自主能力丧失以及各种原因导致的死亡风险增加有关。有研究表明，定期进行体育锻炼，尤其是有氧运动训练（AT），有助于实现更好的健康老龄化。我们进行了一项荟萃分析，以衡量AT对70岁及以上老年人VO的确切益处。使用关键词在Embase、Medline、PubMed Central、ScienceDirect、Scopus和Web of Science中对文章进行了全面、系统的数据库搜索。两名评审员独立评估潜在纳入的干预性研究。共纳入了10项随机对照试验（RCT），总计348名70岁及以上的老年人。在所有试验中，未发现高偏倚风险，且所有试验均将开放标签组作为对照组。由于RCT之间存在显著异质性（所有p < 0.001），因此对VO进行了汇总分析。在对10项RCT的汇总分析中，不仅发现训练组的VO显著高于对照组（平均差[MD] = 1.56；95%置信区间[CI]：0.90 - 2.23），而且在根据参与者的健康状况进行调整分析时也是如此。健康和不健康老年人的MD分别为1.72（95% CI：0.34 - 3.10）和1.47（95% CI：0.60 - 2.34）。这项荟萃分析证实了AT对健康和不健康老年人VO的有益影响。
