Almaw Andargachew, Berhan Ayenew, Ayele Addisu, Fentie Alemie, Abebaw Aynework, Malkamu Birhanemaskal, Getie Birhanu, Erkihun Mulat, Solomon Yenealem, Eyayu Tahir, Kiros Teklehaimanot
Department of Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Gut Pathog. 2024 Sep 19;16(1):48. doi: 10.1186/s13099-024-00642-8.
The urease-producing Helicobacter pylori increase the likelihood that pathogenic intestinal protozoa will use the stomach's increased hydrogen potential to propagate the disease. Coinfections exacerbate the onset and severity of gastrointestinal symptoms. This study aimed to assess the prevalence of intestinal parasites/Helicobacter pylori coinfection and contributing factors in patients with gastrointestinal symptoms at Addis Zemen Primary Hospital, Northwest Ethiopia.
From April to July 2023, patients with gastrointestinal problems participated in a cross-sectional study carried out in a hospital. To collect the clinical and sociodemographic data, a questionnaire was employed. Intestinal parasites and Helicobacter pylori were detected using the saline stool wet mount and Helicobacter pylori stool antigen tests, respectively. SPSS version 20 was used to analyze the data and variables with p-values < 0.05 were considered statistically significant.
The study included 384 participants in total, of which 47.3% (182/384) were farmers and 50.3% (193/384) were women. Of the study subjects, 69/384 or approximately 18%, had intestinal parasitic infections. In 12% of cases (46/384), Helicobacter pylori were detected. A coinfection of Helicobacter pylori and intestinal parasites was found in 5.5% (21/384) of the subjects. Multiple logistic regression revealed increased risk of coinfection of Helicobacter pylori and intestinal parasites in patients who drink surface water (AOR: 10.7, p = 0.03) family history of Helicobacter pylori (AOR: 3.3, p = 0.024) and those with untrimmed fingers (AOR: 4.9, p = 0.031).
Giardia lamblia and Entamoeba histolytica/dispar/ moshkovskii/ bangladeshi complex are the most common protozoans that cause coinfection with Helicobacter pylori. Drinking surface water, family history of Helicobacter pylori and untrimmed fingers are the contributing factors to intestinal parasites/Helicobacter pylori coinfection.
产脲酶的幽门螺杆菌增加了致病性肠道原生动物利用胃中升高的氢电位传播疾病的可能性。合并感染会加剧胃肠道症状的发作和严重程度。本研究旨在评估埃塞俄比亚西北部亚的斯泽门初级医院有胃肠道症状患者中肠道寄生虫/幽门螺杆菌合并感染的患病率及相关因素。
2023年4月至7月，有胃肠道问题的患者参与了在一家医院开展的横断面研究。采用问卷调查收集临床和社会人口学数据。分别使用生理盐水粪便湿片法和幽门螺杆菌粪便抗原检测法检测肠道寄生虫和幽门螺杆菌。使用SPSS 20版分析数据，p值<0.05的变量被认为具有统计学意义。
该研究共纳入384名参与者，其中47.3%（182/384）为农民，50.3%（193/384）为女性。在研究对象中，69/384（约18%）有肠道寄生虫感染。在12%的病例（46/384）中检测到幽门螺杆菌。5.5%（21/384）的受试者存在幽门螺杆菌和肠道寄生虫合并感染。多因素logistic回归显示，饮用地表水的患者（调整后比值比：10.7，p = 0.03）、有幽门螺杆菌家族史的患者（调整后比值比：3.3，p = 0.024）以及手指未修剪的患者（调整后比值比：4.9，p = 0.031）幽门螺杆菌和肠道寄生虫合并感染的风险增加。
蓝氏贾第鞭毛虫和溶组织内阿米巴/迪氏内阿米巴/莫斯科维内阿米巴/孟加拉内阿米巴复合体是最常见的与幽门螺杆菌合并感染的原生动物。饮用地表水、幽门螺杆菌家族史和手指未修剪是肠道寄生虫/幽门螺杆菌合并感染的影响因素。
