Department of Biological Sciences, Centre for Bioimaging Sciences, Mechanobiology Institute, National University of Singapore, Singapore
J Cell Biol. 2017 Dec 4;216(12):3899-3901. doi: 10.1083/jcb.201710079. Epub 2017 Nov 14.
The nature of signal transduction networks in the regulation of cell contractility is not entirely clear. In this study, Graessl et al. (2017. https://doi.org/10.1083/jcb.201706052) visualized and characterized pulses and waves of Rho activation in adherent cells and proposed excitable Rho signaling networks underlying cell contractility.
信号转导网络在调节细胞收缩性方面的性质尚不完全清楚。在这项研究中,Graessl 等人(2017 年,https://doi.org/10.1083/jcb.201706052)可视化并描述了贴壁细胞中 Rho 激活的脉冲和波,并提出了细胞收缩性的可兴奋 Rho 信号网络。