a State Key Laboratory of Food Science and Technology , School of Food Science and Technology, Nanchang University , Nanchang , China.
b School of Public Health , Nanchang University , Nanchang , China.
Int J Food Sci Nutr. 2018 Aug;69(5):566-573. doi: 10.1080/09637486.2017.1394449. Epub 2017 Nov 15.
Chlorogenic acid (CGA) has many biological properties, including antibacterial, antioxidant and anti-inflammatory properties, and is one of the most abundant phenolic acids available in the human diet. The aim of this study was to investigate the effects of CGA on regulation of the gut microbiota, and on the levels of free amino acids and 5-hydroxytryptamine (5-HT, serotonin). Ninety-six healthy growing pigs were randomly assigned to two treatment groups: the Ctrl group (control group, standard feed) and the CGA group [standard feed plus 0.05% 3-caffeoylquinic acid (3-CQA)] for 60 days. The diversity of the gut microbiota was increased after CGA supplementation. Changes in these microbes were significantly associated with the serum free amino acid levels and colonic 5-HT level. Compared with the Ctrl group, the levels of serum aspartic acid, threonine, alanine, arginine, and colonic 5-HT were significantly increased (p < .05). These data suggest important roles for CGA in regulating the gut microbiota and increasing the serum free amino acid levels.
绿原酸（CGA）具有许多生物学特性，包括抗菌、抗氧化和抗炎特性，是人类饮食中含量最丰富的酚酸之一。本研究旨在探讨 CGA 对肠道微生物群的调节作用，以及对游离氨基酸和 5-羟色胺（5-HT，血清素）水平的影响。96 头健康生长猪被随机分为两组：对照组（标准饲料）和 CGA 组[标准饲料加 0.05%3-咖啡酰奎尼酸（3-CQA）]，共 60 天。CGA 补充后，肠道微生物群的多样性增加。这些微生物的变化与血清游离氨基酸水平和结肠 5-HT 水平显著相关。与对照组相比，血清天冬氨酸、苏氨酸、丙氨酸、精氨酸和结肠 5-HT 水平显著升高（p<0.05）。这些数据表明 CGA 在调节肠道微生物群和增加血清游离氨基酸水平方面发挥着重要作用。
