Aiello Florencia, Dueñas Eliana P, Musso Carlos G
Human Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires C1199ABB, Argentina.
Family Physician Department, Universidad del Valle, Valle del Cauca 760001, Colombia.
Healthcare (Basel). 2017 Oct 28;5(4):81. doi: 10.3390/healthcare5040081.
Chronic kidney disease (CKD) is a condition characterized by progressive and irreversible deterioration of renal function due to the reduction of nephron mass for a period of at least three months. The prevalence of CKD is roughly 10% in the general population but increases with age, affecting more than one-third of people older than 65. Frailty is a condition usually found in elderly people, characterized by weakness, motility, and balance issues, with a declined ability to resist stressors leading to increased risks of adverse health outcomes including falls, fracture, hospitalization, institutionalization, disability, dependence, dementia, poor quality of life, and death. There is interdependence between CKD and normal ageing whereby CKD makes ageing more accelerated and pronounced (senescence), whereas senescence accelerates chronic nephropathy's progression. Frailty status catalyzes this spiral, with renal and systemic consequences, phenomenon which can be named senescent nephropathy. In conclusion, senescent nephropathy is a new renal syndrome that should be taken into account, and we must try to handle its appearance and progression not only by applying nephron prevention measurements but also by diagnosis and treating frailty in the CKD population.
慢性肾脏病（CKD）是一种由于肾单位数量减少导致肾功能进行性和不可逆恶化，且病程至少持续三个月的病症。CKD在普通人群中的患病率约为10%，但随年龄增长而升高，65岁以上人群中超过三分之一受其影响。衰弱是一种常见于老年人的状况，其特征为虚弱、运动和平衡问题，抵抗应激源的能力下降，导致包括跌倒、骨折、住院、入住养老院、残疾、依赖、痴呆、生活质量差及死亡等不良健康后果的风险增加。CKD与正常衰老之间存在相互依存关系，即CKD使衰老加速且更为明显（衰老），而衰老则加速慢性肾病的进展。衰弱状态加剧了这种恶性循环，产生肾脏和全身影响，这种现象可称为衰老性肾病。总之，衰老性肾病是一种应予以考虑的新的肾脏综合征，我们不仅必须通过采取肾单位预防措施，还需通过诊断和治疗CKD人群中的衰弱来应对其出现和进展。
