2-正辛基-4-异噻唑啉-3-酮（Skane M-8）的刺激性和致敏性及斑贴试验浓度建议
The irritancy and allergenicity of 2-n-octyl-4-isothiazolin-3-one (Skane M-8), with recommendations for patch test concentration.
作者信息
Emmett E A, Ng S K, Levy M A, Moss J N, Morici I J
机构信息
Centre for Occupational Environmental Health, School of Hygiene and Public Health, John Hopkins University.
出版信息
Contact Dermatitis. 1989 Jan;20(1):21-6. doi: 10.1111/j.1600-0536.1989.tb03090.x.
Preparations of 2-n-octyl-4-isothiazolin-3-one (Skane M-8) at 1000 p.p.m. a.i. and 500 p.p.m. a.i. in pet. induced allergy in a cumulative insult human patch test. Challenge patch testing using 250 p.p.m. a.i. Skane M-8 elicited allergy in 6 out of 6 sensitized individuals. Sensitized individuals did not cross react with Kathon biocide, (Kathon CG), a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one. All pretrolatum preparations to which Tween 85 was added at 2.5% produced mild irritation in cumulative insult patch tests, but no irritation was observed with Tween 85 at 0.625%. We conclude that Skane M-8, 250 p.p.m. a.i. with Tween 85 0.625% in petrolatum is appropriate for patch testing for Skane M-8 allergy.
在累积激发人体斑贴试验中，含1000 ppm有效成分和500 ppm有效成分的2-正辛基-4-异噻唑啉-3-酮（Skane M-8）凡士林制剂可诱发过敏。使用250 ppm有效成分的Skane M-8进行激发斑贴试验，6名致敏个体中有6人出现过敏反应。致敏个体与凯松杀菌剂（Kathon CG，5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮的混合物）无交叉反应。在累积激发斑贴试验中，所有添加2.5%吐温85的凡士林制剂均产生轻度刺激，但0.625%吐温85未观察到刺激。我们得出结论，含250 ppm有效成分Skane M-8和0.625%吐温85的凡士林制剂适用于Skane M-8过敏的斑贴试验。
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