Bruze M, Gruvberger B, Persson K
Department of Occupational Dermatology, University Hospital, Lund, Sweden.
Derm Beruf Umwelt. 1987 Sep-Oct;35(5):165-8.
Kathon CG is a commercial preservative, consisting of the two active ingredients, 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one (5243-K-CG) and other components. 4,5-dichloro-2-methyl-4-isothiazolin-3-one (45243-K-CG) is a contaminant in Kathon CG. The chemically related active ingredients are known to be contact sensitizers in humans and guinea pigs. Aims of this study were to determine the sensitizing capacity of this contaminant and also to investigate the cross-reaction pattern by guinea pig sensitization tests. 45243-K-CG was demonstrated to be a strong sensitizer; all animals reacting to 45243-K-CG also reacted to 5243-K-CG when rechallenged.
卡松CG是一种商业防腐剂，由两种活性成分2-甲基-4-异噻唑啉-3-酮和5-氯-2-甲基-4-异噻唑啉-3-酮（5243-K-CG）以及其他成分组成。4,5-二氯-2-甲基-4-异噻唑啉-3-酮（45243-K-CG）是卡松CG中的一种污染物。已知这些化学相关的活性成分在人类和豚鼠中是接触性致敏原。本研究的目的是确定这种污染物的致敏能力，并通过豚鼠致敏试验研究交叉反应模式。结果表明45243-K-CG是一种强致敏原；再次激发时，所有对45243-K-CG产生反应的动物对5243-K-CG也产生了反应。
