Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health, Peking University Health Science Center, 38 Xueyuan Rd., Beijing 100191, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, 38 Xueyuan Rd., Beijing 100191, China.
Nutrients. 2017 Nov 16;9(11):1256. doi: 10.3390/nu9111256.
Adequate docosahexaenoic acid (DHA) is essential for the optimal growth and development of the fetus. Maternal DHA content fluctuates during pregnancy. The correlation of DHA content with dietary intake might be varied over the course of pregnancy. We aimed to compare the dietary DHA intake, estimated by a DHA-specific semiquantitative food frequency questionnaire (FFQ) against its blood content, among mid- and late-term pregnant women. A total of 804 Chinese pregnant women completed the tailored FFQ and provided fasting venous blood samples. Dietary DHA intake (mg/day) in the previous month was calculated from the FFQ using Chinese Food Composition Table. DHA concentrations (weight percent of total fatty acids) in plasma and erythrocytes were measured by capillary gas chromatography. Spearman correlation coefficients () between DHA intake and its relative concentrations were calculated. After adjustment for maternal age, pre-pregnancy body mass index, stage of pregnancy, parity, education level, ethnicity, and annual family income per capita, the correlation coefficients of DHA intake with its concentrations in plasma and erythrocytes were 0.35 and 0.33, respectively ( < 0.001). The correlations were relatively stronger among women in late pregnancy ( = 0.44 in plasma and 0.39 in erythrocytes) than those in mid-pregnancy ( = 0.25 and 0.26). The significant correlations were consistently observed in subgroups stratified by regions, except for erythrocytes in women living in a coastland area. Multiple regression analyses also indicated significant positive linear correlations between DHA intake and its plasma or erythrocytes concentrations ( < 0.001). In conclusion, dietary DHA intake, estimated by the FFQ, was positively correlated with its concentrations in plasma and erythrocytes in Chinese pregnant women, especially for women in late pregnancy, with the exception of the erythrocytes of those living in a coastland area.
足够的二十二碳六烯酸 (DHA) 是胎儿最佳生长和发育所必需的。孕妇体内的 DHA 含量在怀孕期间波动。DHA 含量与饮食摄入的相关性可能在整个孕期都有所不同。我们旨在比较中晚期孕妇通过 DHA 特异性半定量食物频率问卷 (FFQ) 估计的饮食 DHA 摄入量与其血液含量。共有 804 名中国孕妇完成了定制的 FFQ，并提供了空腹静脉血样。通过中国食物成分表从 FFQ 计算出前一个月的膳食 DHA 摄入量 (mg/天)。通过毛细管气相色谱法测量血浆和红细胞中 DHA 浓度 (总脂肪酸重量百分比)。计算 DHA 摄入量与其相对浓度之间的 Spearman 相关系数 ()。在校正了母亲的年龄、孕前体重指数、妊娠阶段、产次、教育水平、种族和人均年家庭收入后，DHA 摄入量与血浆和红细胞中浓度的相关系数分别为 0.35 和 0.33（<0.001）。在晚期妊娠的女性中，相关性较强（血浆中为 0.44，红细胞中为 0.39），而在中期妊娠的女性中，相关性较弱（血浆中为 0.25，红细胞中为 0.26）。除沿海地区女性的红细胞外，在按地区分层的亚组中，均观察到显著相关性。多元回归分析也表明 DHA 摄入量与血浆或红细胞浓度之间存在显著的正线性相关（<0.001）。总之，通过 FFQ 估计的饮食 DHA 摄入量与中国孕妇血浆和红细胞中的 DHA 浓度呈正相关，尤其是在晚期妊娠的女性中，除了生活在沿海地区的女性的红细胞外。
Zotero 插件