神经发生的神经胶质控制。

Glial control of neurogenesis.

机构信息

Physiological Genomics, Biomedical Center, Ludwig Maximilians University Munich, 82152 Planegg/Munich, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany; SYNERGY, Excellence Cluster of Systems Neurology, Biomedical Center, Ludwig-Maximilian University Munich, 82152 Planegg/Munich, Germany.

出版信息

Curr Opin Neurobiol. 2017 Dec;47:188-195. doi: 10.1016/j.conb.2017.10.025. Epub 2017 Nov 13.

DOI:10.1016/j.conb.2017.10.025

PMID:29145015

Abstract

Glial cells are central components of all neurogenic niches in the embryonic as well as in the adult central nervous system. While neural stem cells (NSCs) themselves exhibit glial features the behavior of NSCs is also strongly influenced by niche glial cells. Recently, studies have begun to uncover a large variety of glial cell-extrinsic as well as intrinsic factors that play crucial roles in the control of NSCs and the regulation of the cellular output from the neurogenic niches. In this review, we focus on mechanisms underlying the formation of adult NSCs by embryonic radial glia cells, discuss the influence of niche glia cells on adult NSCs and examine how the neurogenic potential of glial cells is controlled.

摘要

胶质细胞是胚胎期和成年中枢神经系统所有神经发生龛的核心组成部分。虽然神经干细胞（NSC）本身具有胶质细胞的特征，但 NSC 的行为也受到龛位胶质细胞的强烈影响。最近的研究开始揭示出大量胶质细胞外在和内在因素，这些因素在 NSC 的控制和神经发生龛的细胞输出调节中起着关键作用。在这篇综述中，我们重点讨论胚胎放射状胶质细胞形成成年 NSC 的机制，讨论龛位胶质细胞对成年 NSC 的影响，并研究胶质细胞的神经发生潜能是如何被控制的。