Eberhard Daniel, Lammert Eckhard
Institute of Metabolic Physiology, Department of Biology, Heinrich Heine University, D-40225, Düsseldorf, Germany.
Institute for Beta Cell Biology, German Diabetes Center, Leibniz Center for Diabetes, Research at Heinrich Heine University, D-40225, Düsseldorf, Germany.
Adv Exp Med Biol. 2017;1037:173-186. doi: 10.1007/978-981-10-6583-5_11.
Type 2 diabetes mellitus (T2DM) is a worldwide escalating health disorder resulting from insulin resistance and functional loss of insulin-producing beta cells that finally cause chronically elevated blood glucose concentrations. Here we review the role of ubiquitously expressed antioxidant protein DJ-1 in the pathogenesis of T2DM. In beta cells, DJ-1 protects against oxidative stress, endoplasmic reticulum stress, and streptozotocin- and cytokine-induced stress and preserves beta cell viability and insulin secretion. In skeletal muscle, DJ-1 controls energy metabolism and efficient fuel utilization, whereas in adipose tissue a role in adipogenesis and obesity-induced inflammation has been reported. This suggests that DJ-1 plays multiple roles in many cell types under metabolically challenging conditions as seen in obesity, insulin resistance, and T2DM.
2型糖尿病（T2DM）是一种在全球范围内不断升级的健康疾病，由胰岛素抵抗和产生胰岛素的β细胞功能丧失引起，最终导致血糖浓度长期升高。在此，我们综述了普遍表达的抗氧化蛋白DJ-1在T2DM发病机制中的作用。在β细胞中，DJ-1可抵御氧化应激、内质网应激以及链脲佐菌素和细胞因子诱导的应激，并维持β细胞活力和胰岛素分泌。在骨骼肌中，DJ-1控制能量代谢和有效的燃料利用，而在脂肪组织中，DJ-1在脂肪生成和肥胖诱导的炎症中发挥作用。这表明，在肥胖、胰岛素抵抗和T2DM等代谢挑战性条件下，DJ-1在多种细胞类型中发挥多种作用。
