McChesney S L, Withrow S J, Gillette E L, Powers B E, Dewhirst M W
Comparative Oncology Unit, Colorado State University, Fort Collins 80523.
J Am Vet Med Assoc. 1989 Jan 1;194(1):60-3.
Megavoltage radiotherapy was administered to 42 dogs with soft tissue sarcoma. Acceptable local control of these aggressive tumors was achieved after one year of treatment. Control rates of 48 and 67% were obtained at doses of 45 and 50 gray (Gy), respectively. At 2 years, control rates decreased to 33% at the dose of 50 Gy. Serious complications developed in 4 of 42 dogs at doses of 40 to 50 Gy. The estimated dose with a 50% probability for causing serious complications was 54 Gy, given in 10 fractions. We believe that the large doses per fraction used in this study probably led to an increased probability for necrosis. Hemangiopericytomas seemed to be more responsive than fibrosarcomas. Only 2 of 11 recurrent tumors were controlled with surgery. Good local control was achieved with radiation alone for one year at doses with a low probability for serious complications; however, higher total radiation doses or combined modalities, such as surgery and radiation or radiation and hyperthermia, may be needed for longer-term control.
对42只患有软组织肉瘤的犬进行了兆伏级放疗。经过一年的治疗，这些侵袭性肿瘤获得了可接受的局部控制。在45和50格雷（Gy）剂量下，控制率分别为48%和67%。在2年时，50 Gy剂量下的控制率降至33%。42只犬中有4只在40至50 Gy剂量下出现了严重并发症。以10次分割给予时，导致严重并发症的50%概率的估计剂量为54 Gy。我们认为本研究中使用的每分次大剂量可能导致坏死概率增加。血管外皮细胞瘤似乎比纤维肉瘤更敏感。11例复发性肿瘤中只有2例通过手术得到控制。在严重并发症概率较低的剂量下，单独放疗一年可实现良好的局部控制；然而，对于长期控制可能需要更高的总辐射剂量或联合治疗方式，如手术与放疗或放疗与热疗。
