Graduate College of Social Work, University of Houston, Houston, Texas.
School of Social Work, University of Michigan, Ann Arbor, Michigan.
Cancer. 2018 Jan 15;124(2):398-405. doi: 10.1002/cncr.31030. Epub 2017 Nov 17.
Cancer-related sexual dysfunction has been reported among adolescents and young adults (AYAs); however, its prevalence over time has not been examined. This longitudinal study investigated sexual dysfunction in AYAs over the course of 2 years after the initial diagnosis.
Young adult patients (18-39 years old) completed the Medical Outcomes Study Sexual Functioning Scale within the first 4 months of their diagnosis (n = 123) and again 6 (n = 107) and 24 months later (n = 95). An ordered multinomial response model analyzed changes in the probability of reporting sexual dysfunction over time and the independent effects of demographic, clinical, and psychosocial variables.
More than half of the participants reported sexual functioning to be problematic at each assessment. The probability of reporting sexual dysfunction increased over time (P < .01) and was greater for cancer patients who were female (P < .001), older (P < .01), married or in a committed relationship (P < .001), treated with chemotherapy (P < .05), and reporting comorbid psychological distress (P < .001) and lower social support (P < .05). For women, being in a relationship increased the likelihood of reporting sexual problems over time; for men, the likelihood of reporting sexual problems increased regardless of their relationship status.
A substantial proportion of young adults report ongoing problems with sexual functioning in the first 2 years after their cancer diagnosis. These findings justify the need to evaluate and monitor sexual functioning throughout a continuum of care. Cancer 2018;124:398-405. © 2017 American Cancer Society.
癌症相关的性功能障碍已在青少年和年轻成年人（AYA）中报告；然而，其随时间的流行率尚未被研究。这项纵向研究调查了 AYA 在初始诊断后 2 年内的性功能障碍。
年轻的成年患者（18-39 岁）在诊断的前 4 个月内（n = 123）和 6 个月后（n = 107）和 24 个月后（n = 95）完成了医疗结果研究性功能量表。有序多项反应模型分析了随时间报告性功能障碍的概率变化以及人口统计学，临床和心理社会变量的独立影响。
超过一半的参与者在每次评估中都报告了性功能障碍。报告性功能障碍的概率随时间增加（P <.01），并且对于女性（P <.001），年龄较大（P <.01），已婚或处于承诺关系（P <.001），接受化学疗法治疗（P <.05）和报告合并心理困扰（P <.001）和较低的社会支持（P <.05）的癌症患者更大。对于女性，处于关系中会随着时间的推移增加报告性问题的可能性；对于男性，无论其关系状况如何，报告性问题的可能性都会增加。
相当一部分年轻人在癌症诊断后的头 2 年内报告持续存在性功能障碍。这些发现证明了在整个护理连续体中评估和监测性功能的必要性。癌症 2018;124:398-405。©2017 美国癌症协会。
