Shu Jicheng, Li Linyu, Zhou Meng, Yu Jiangli, Peng Caiying, Shao Feng, Liu Ronghua, Zhu Genhua, Huang Huilian
a Key Laboratory of Modern Preparation of TCM , Jiangxi University of Traditional Chinese Medicine, Ministry of Education , Nanchang , China.
Nat Prod Res. 2018 Aug;32(15):1760-1768. doi: 10.1080/14786419.2017.1402314. Epub 2017 Nov 17.
Three new flavonoid glycosides, 2(S)-5-hydroxy-6,8-dimethoxyflavonone-7-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (1), 5-hydroxy-3,8-dimethoxyflavone-7-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (2) and 3,7-dihydroxy-8-methoxyflavone-6-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (3), together with five known flavonoids (4-8) were isolated from the roots of Smilax glabra Roxb. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Three new flavonoids were subjected to evaluate anti-inflammatory activity. Compounds 1-3 inhibited the NF κB induction by 32.2, 55.8 and 61.7%, respectively.
从光叶菝葜根中分离得到3个新的黄酮苷，即2(S)-5-羟基-6,8-二甲氧基黄酮-7-O-β-D-吡喃葡萄糖基-(1→6)-O-β-D-吡喃葡萄糖苷（1）、5-羟基-3,8-二甲氧基黄酮-7-O-β-D-吡喃葡萄糖基-(1→6)-O-β-D-吡喃葡萄糖苷（2）和3,7-二羟基-8-甲氧基黄酮-6-O-β-D-吡喃葡萄糖基-(1→6)-O-β-D-吡喃葡萄糖苷（3），以及5个已知黄酮类化合物（4 - 8）。通过化学和光谱数据以及与文献数据对比，阐明了它们的结构。对3个新黄酮类化合物进行了抗炎活性评价。化合物1 - 3分别抑制NF-κB诱导达32.2%、55.8%和61.7%。
