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天然产物在类风湿性关节炎中的作用：基础体外和体内研究的当前知识

The Role of Natural Products in Rheumatoid Arthritis: Current Knowledge of Basic In Vitro and In Vivo Research.

作者信息

Deligiannidou Georgia-Eirini, Gougoula Vasiliki, Bezirtzoglou Eugenia, Kontogiorgis Christos, Constantinides Theodoros K

机构信息

Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, GR-68100 Alexandroupolis, Greece.

Institute of Agri-Food and Life Sciences, Hellenic Mediterranean University Research Centre, GR-71410 Heraklion, Greece.

出版信息

Antioxidants (Basel). 2021 Apr 13;10(4):599. doi: 10.3390/antiox10040599.

DOI:10.3390/antiox10040599
PMID:33924632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8070014/
Abstract

Rheumatoid arthritis (RA) is an autoimmune disorder affecting a vast variety of the population. The onset of RA as well as the development of systematic immunization is affected by both genetic and environmental risk factors. This review aims to point out the role of natural products in the management of RA, focusing on the reports of basic research (in vitro and animal studies) emphasizing the antioxidant and anti-inflammatory properties considered in the field of RA. A systematic screening of the relevant literature was carried out on PubMed, Google Scholar, and Scopus with the following criteria: publication date, 2015-2020; language, English; study design, in vitro or animal models; and the investigation of one or several natural products in the context of RA, including, when available, the molecular mechanisms implicated. A total of 211 papers were initially obtained and screened. In vitro and animal studies referring to 20 natural products and 15 pure compounds were ultimately included in this review. The outcomes of this work provide an overview of the methods employed in basic research over the past five years, with emphasis on the limitations presented, while demonstrating the potential benefits of utilizing natural products in the management of RA as supported by in vitro and animal studies.

摘要

类风湿性关节炎（RA）是一种影响众多人群的自身免疫性疾病。RA的发病以及系统性免疫反应的发展受到遗传和环境风险因素的影响。本综述旨在指出天然产物在RA治疗中的作用，重点关注基础研究（体外和动物研究）报告，这些研究强调了RA领域中所考虑的抗氧化和抗炎特性。在PubMed、谷歌学术和Scopus上对相关文献进行了系统筛选，筛选标准如下：出版日期为2015 - 2020年；语言为英语；研究设计为体外或动物模型；以及在RA背景下对一种或几种天然产物的研究，包括（如有）涉及的分子机制。最初共获得并筛选了211篇论文。本综述最终纳入了涉及20种天然产物和15种纯化合物的体外和动物研究。这项工作的结果概述了过去五年基础研究中所采用的方法，重点介绍了所呈现的局限性，同时展示了体外和动物研究支持的在RA治疗中使用天然产物的潜在益处。

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