Liu Xuehong, Zhang Yong, Yang Yang, Lin Jingquan, Huo Xue, Du Xiaoxue, Botchway Benson O A, Fang Marong
Department of Histology and Embryology, Shaoxing University School of Medicine, Shaoxing City, Zhejiang Province, China.
Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.
Anat Rec (Hoboken). 2018 Apr;301(4):686-696. doi: 10.1002/ar.23729. Epub 2017 Nov 28.
In addition to imperiling an individual's daily life, spinal cord injury (SCI), a catastrophic medical damage, can permanently impair an individual's body function. Methylprednisolone (MP), a medically accepted therapeutic drug for SCI, is highly controversial for the lack of consensus on its true therapeutic effect. In recent years, curcumin has served as a potential and novel therapeutic drug in SCI. Our study was intended to investigate the precise effect of MP and curcumin in SCI. We examined the function of MP and curcumin in a SCI model rat, both in vivo and in vitro, and found that there was a momentous improvement in Basso-Beattie-Bresnahan scores in the MP-treated group when compared with Cur-treated group within 14 days. Results obtained from the histological, immunohistochemistry and ultrastructural examinations evidenced the curative effect of MP was better than curcumin before Day 14. Nonetheless, there was a significant variation in the treatment effect between the MP-treated and Cur-treated groups after 14 days. The curcumin's effectiveness was more obvious than MP after 14 days following SCI. As such, we surmise that curcumin has a better therapeutic potential than MP with a prolong treatment time in the wake of SCI. Anat Rec, 301:686-696, 2018. © 2017 Wiley Periodicals, Inc.
除了危及个人日常生活外，脊髓损伤（SCI）作为一种灾难性的医学损伤，会永久性损害个体的身体功能。甲基强的松龙（MP）是一种被医学认可用于治疗SCI的药物，但由于对其真正治疗效果缺乏共识，存在很大争议。近年来，姜黄素已成为SCI中一种有潜力的新型治疗药物。我们的研究旨在调查MP和姜黄素在SCI中的精确作用。我们在体内和体外对SCI模型大鼠中MP和姜黄素的功能进行了检测，发现在14天内，与姜黄素治疗组相比，MP治疗组的Basso-Beattie-Bresnahan评分有显著改善。组织学、免疫组化和超微结构检查结果表明，在第14天之前，MP的治疗效果优于姜黄素。然而，14天后，MP治疗组和姜黄素治疗组的治疗效果存在显著差异。SCI后14天，姜黄素的疗效比MP更明显。因此，我们推测，在SCI后延长治疗时间，姜黄素比MP具有更好的治疗潜力。《解剖学记录》，301:686 - 696，2018年。© 2017威利期刊公司。
