Lee Subum, Cho Dae-Chul, Han Inbo, Kim Kyoung-Tae
Department of Neurosurgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
Department of Neurosurgery, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.
Neurospine. 2022 Jun;19(2):249-261. doi: 10.14245/ns.2244148.074. Epub 2022 Jun 30.
Curcumin is a polyphenolic chemical derived from the rhizomes of Curcuma longa. It has been used throughout the Indian subcontinent for medicinal purposes, religious events, and regional cuisine. It has various pharmacological benefits owing to its anti-inflammatory and antioxidant properties. Its neuroprotective effects on the brain and peripheral nerves have been demonstrated in several in vivo neuronal tissue studies. Because of these functional properties of curcumin, it is considered to have great potential for use in the treatment of spinal cord injuries (SCIs). Numerous immunopathological and biochemical studies have reported that curcumin can help prevent and alleviate subsequent secondary injuries, such as inflammation, edema, free radical damage, fibrosis, and glial scarring, after a primary SCI. Furthermore, following SCI, curcumin administration resulted in better outcomes of neurological function recovery as per the Basso, Beattie, and Bresnahan locomotor rating scale. However, to date, its utility in treating SCIs has only been reported in laboratories. More studies on its clinical applications are needed in the future for ensuring its bioavailability across the blood-brain barrier and for verifying the safe dose for treating SCIs in humans.
姜黄素是一种从姜黄根茎中提取的多酚类化合物。在整个印度次大陆，它被用于医疗目的、宗教活动和地方烹饪。由于其抗炎和抗氧化特性，它具有多种药理益处。在多项体内神经元组织研究中已证实其对大脑和周围神经具有神经保护作用。由于姜黄素的这些功能特性，它被认为在治疗脊髓损伤（SCI）方面具有巨大潜力。大量免疫病理学和生物化学研究报告称，姜黄素有助于预防和减轻原发性脊髓损伤后随后发生的继发性损伤，如炎症、水肿、自由基损伤、纤维化和胶质瘢痕形成。此外，根据巴索、比蒂和布雷斯纳汉运动评分量表，脊髓损伤后给予姜黄素可使神经功能恢复取得更好的结果。然而，迄今为止，其在治疗脊髓损伤方面的效用仅在实验室中有报道。未来需要对其临床应用进行更多研究，以确保其穿过血脑屏障的生物利用度，并验证治疗人类脊髓损伤的安全剂量。
