He Guanglin, Li Ye, Wang Zheng, Liang Weibo, Luo Haibo, Liao Miao, Zhang Ji, Yan Jing, Li Yingbi, Hou Yiping, Wu Jin
Department of Forensic Genetics, West China School of Preclinical Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China.
Department of Forensic Genetics, West China School of Preclinical Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China.
Forensic Sci Int Genet. 2017 Nov;31:e33-e35. doi: 10.1016/j.fsigen.2017.07.006. Epub 2017 Jul 17.
Exploration of the ethnic origin and genetic differentiation of 56 Chinese officially recognized nationalities populations played a fundamental role in the research field of population genetics, forensic science, linguistics, anthropology, and archaeology. In the present study, population data of 21 autosomal STR loci (CSF1PO, D10S1248, D12S391, D13S317, D16S539, D18S51, D19S433, D21S11, D2S1338, D2S441, D3S1358, D5S818, D6S1043, D7S820, D8S1179, FGA, Penta D, Penta E, TH01, TPOX, and vWA) included in the AGCU EX22 kit in 2793 Southwest Han Chinese individuals was obtained and population genetic relationships among 28 Chinese populations were investigated. Our study indicated that the twenty-one autosomal STRs are highly polymorphic in the Sichuan Han population and can be used as a powerful tool in the routine forensic usage. MDS and phylogenetic analysis suggested that the Sichuan Han population kept a close genetic relationship with the southwest populations.
对中国56个官方认定民族群体的族源和遗传分化进行探索，在群体遗传学、法医学、语言学、人类学和考古学等研究领域发挥了基础性作用。在本研究中，获取了2793名西南汉族个体中AGCU EX22试剂盒所包含的21个常染色体STR基因座（CSF1PO、D10S1248、D12S391、D13S317、D16S539、D18S51、D19S433、D21S11、D2S1338、D2S441、D3S1358、D5S818、D6S1043、D7S820、D8S1179、FGA、Penta D、Penta E、TH01、TPOX和vWA）的群体数据，并研究了28个中国群体之间的群体遗传关系。我们的研究表明，这21个常染色体STR在四川汉族群体中具有高度多态性，可作为常规法医学应用中的有力工具。多维尺度分析（MDS）和系统发育分析表明，四川汉族群体与西南地区群体保持着密切的遗传关系。
