Center for Global Health and Infectious Diseases Research, Department of Global Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA.
Center for Global Health and Infectious Diseases Research, Department of Global Health, College of Public Health, University of South Florida, Tampa, FL 33612, USA.
Trends Parasitol. 2018 Feb;34(2):114-126. doi: 10.1016/j.pt.2017.10.009. Epub 2017 Nov 16.
Malaria prevalence has declined in the past 10 years, especially outside of sub-Saharan Africa. However, the proportion of cases due to Plasmodium vivax is increasing, accounting for up to 90-100% of the malaria burden in endemic regions. Nonetheless, investments in malaria research and control still prioritize Plasmodium falciparum while largely neglecting P. vivax. Specific biological features of P. vivax, particularly invasion of reticulocytes, occurrence of dormant liver forms of the parasite, and the potential for transmission of sexual-stage parasites prior to onset of clinical illness, promote its persistence and hinder development of research tools and interventions. This review discusses recent advances in P. vivax research, current knowledge of its unique biology, and proposes priorities for P. vivax research and control efforts.
过去 10 年来，疟疾的流行率有所下降，特别是在撒哈拉以南非洲以外地区。然而，由间日疟原虫引起的病例比例正在增加，在流行地区占疟疾负担的 90-100%。尽管如此，疟疾研究和控制的投资仍然优先考虑恶性疟原虫，而在很大程度上忽视了间日疟原虫。间日疟原虫的特定生物学特征，特别是网织红细胞的入侵、寄生虫休眠肝脏形式的发生以及在出现临床疾病之前传播有性阶段寄生虫的潜力，促进了其持续存在，并阻碍了研究工具和干预措施的发展。本综述讨论了间日疟原虫研究的最新进展、对其独特生物学的现有认识，并提出了间日疟原虫研究和控制工作的优先事项。
