School of Distance Learning, Department of Human Sciences, Musashino University, 1-1-20 Shin-machi, Nishitokyo-shi, Tokyo 202-8585, Japan.
Department of Mental Health Policy and Evaluation, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
Prostaglandins Leukot Essent Fatty Acids. 2017 Dec;127:1-5. doi: 10.1016/j.plefa.2017.09.018. Epub 2017 Sep 28.
Empirical evidence is divided on whether n-3 polyunsaturated fatty acid levels are associated with quality of life (QOL). This study investigated the effects of docosahexaenoic acid (DHA) supplementation on QOL in survivors of traumatic injury. In this secondary analysis of a double-blind, randomized controlled trial, we recruited 110 trauma patients (82% men; mean age, 39.6 years) in an intensive care unit. Fifty-three received DHA-rich supplements and 57 received placebo for 12 weeks. We used the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) to assess QOL at the end of intervention. DHA did not significantly affect any QOL domain on the SF-36 after 12 weeks. In the DHA group, changes in the erythrocyte levels of eicosapentaenoic acid (EPA) + DHA and EPA were positively correlated with the SF-36 mental component. DHA did not influence QOL of trauma patients, but increased EPA levels during the trial were associated with better QOL in patients receiving omega-3.
关于 n-3 多不饱和脂肪酸水平是否与生活质量（QOL）相关，实证证据存在分歧。本研究调查了二十二碳六烯酸（DHA）补充剂对创伤幸存者生活质量的影响。在这项双盲、随机对照试验的二次分析中，我们招募了 110 名重症监护病房的创伤患者（82%为男性；平均年龄 39.6 岁）。53 名患者接受富含 DHA 的补充剂，57 名患者接受安慰剂治疗 12 周。我们使用医疗结局研究 36 项简短健康调查问卷（SF-36）在干预结束时评估生活质量。12 周后，DHA 对 SF-36 任何生活质量领域均无显著影响。在 DHA 组中，红细胞中二十碳五烯酸（EPA）+DHA 和 EPA 的变化与 SF-36 心理成分呈正相关。DHA 对创伤患者的生活质量没有影响，但试验期间 EPA 水平的增加与接受ω-3 的患者更好的生活质量相关。
