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使用抗表皮生长因子受体-金纳米棒偶联物的近红外光热疗法治疗三阴性乳腺癌。

Near-infrared photothermal therapy using anti-EGFR-gold nanorod conjugates for triple negative breast cancer.

作者信息

Zhang Meihua, Kim Hoe Suk, Jin Tiefeng, Woo Jisu, Piao Yin Ji, Moon Woo Kyung

机构信息

Department of Radiology, Seoul National University Hospital, Jongno-gu, Seoul 03080, Korea.

Department of Biomedical Sciences, Seoul National University College of Medicine, Jongno-gu, Seoul 110-799, Korea.

出版信息

Oncotarget. 2017 Sep 23;8(49):86566-86575. doi: 10.18632/oncotarget.21243. eCollection 2017 Oct 17.

DOI:10.18632/oncotarget.21243
PMID:29156817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5689707/
Abstract

Current EGFR-targeted therapy for triple negative breast cancer (TNBC) has produced disappointing results. A rational therapeutic strategy to improve EGFR-targeted treatment for TNBC is therefore needed. In this study we evaluated the feasibility of treating TNBC using photoacoustic imaging (PAI)-guided near-infrared photothermal therapy (NIR-PTT) with anti-EGFR-conjugated gold nanorods (anti-EGFR-GN). NIR-PTT combined with anti-EGFR-GN exerted synergistic anti-proliferative and apoptotic actions through upregulation of HSP70 and cleaved caspase-3, downregulation of Ki-67 and EGFR, and inhibition of several intracellular signaling molecules (mTOR, AKT, ERK1/2 and FAK). These combined effects give this approach significant efficacy. Our findings suggest PAI-guided NIR-PTT using anti-EGFR-GN represent a novel and effective strategy for EGFR-targeted therapy in TNBC.

摘要

目前针对三阴性乳腺癌（TNBC）的表皮生长因子受体（EGFR）靶向治疗效果令人失望。因此，需要一种合理的治疗策略来改善TNBC的EGFR靶向治疗。在本研究中，我们评估了使用光声成像（PAI）引导的近红外光热疗法（NIR-PTT）联合抗EGFR偶联金纳米棒（anti-EGFR-GN）治疗TNBC的可行性。NIR-PTT联合anti-EGFR-GN通过上调热休克蛋白70（HSP70）和裂解的半胱天冬酶-3（cleaved caspase-3）、下调Ki-67和EGFR以及抑制几种细胞内信号分子（哺乳动物雷帕霉素靶蛋白（mTOR）、蛋白激酶B（AKT）、细胞外信号调节激酶1/2（ERK1/2）和黏着斑激酶（FAK））发挥协同抗增殖和凋亡作用。这些联合效应赋予了这种方法显著的疗效。我们的研究结果表明，使用anti-EGFR-GN的PAI引导的NIR-PTT是TNBC中EGFR靶向治疗的一种新型有效策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f7/5689707/8fab111e8a57/oncotarget-08-86566-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f7/5689707/daca6b6443de/oncotarget-08-86566-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f7/5689707/f74233cf24d8/oncotarget-08-86566-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f7/5689707/7ffa75bc937f/oncotarget-08-86566-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f7/5689707/8fab111e8a57/oncotarget-08-86566-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f7/5689707/daca6b6443de/oncotarget-08-86566-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f7/5689707/f74233cf24d8/oncotarget-08-86566-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f7/5689707/7ffa75bc937f/oncotarget-08-86566-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03f7/5689707/8fab111e8a57/oncotarget-08-86566-g004.jpg

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[2]
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Pharmaceutics. 2023-1-18

[4]
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Pharmaceutics. 2023-1-11

[5]
Recent advances in photothermal therapy-based multifunctional nanoplatforms for breast cancer.

Front Chem. 2022-9-19

[6]
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Nanoscale Adv. 2019-7-23

[7]
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[8]
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本文引用的文献

[1]
Near-infrared photothermal therapy using EGFR-targeted gold nanoparticles increases autophagic cell death in breast cancer.

J Photochem Photobiol B. 2017-3-30

[2]
Application of Gold Nanorods for Photothermal Therapy in Ex Vivo Human Oesophagogastric Adenocarcinoma.

J Biomed Nanotechnol. 2016-3

[3]
Ultrasound-guided photoacoustic imaging for the selective detection of EGFR-expressing breast cancer and lymph node metastases.

Biomed Opt Express. 2016-4-19

[4]
Current Approaches of Photothermal Therapy in Treating Cancer Metastasis with Nanotherapeutics.

Theranostics. 2016-3-21

[5]
Erythrocyte membrane is an alternative coating to polyethylene glycol for prolonging the circulation lifetime of gold nanocages for photothermal therapy.

ACS Nano. 2014-10-9

[6]
Sentinel lymph node biopsy revisited: ultrasound-guided photoacoustic detection of micrometastases using molecularly targeted plasmonic nanosensors.

Cancer Res. 2014-8-8

[7]
Tumor metastasis inhibition by imaging-guided photothermal therapy with single-walled carbon nanotubes.

Adv Mater. 2014-6-13

[8]
Photoacoustic microscopy and computed tomography: from bench to bedside.

Annu Rev Biomed Eng. 2014-7-11

[9]
Gold nanoshelled liquid perfluorocarbon nanocapsules for combined dual modal ultrasound/CT imaging and photothermal therapy of cancer.

Small. 2014-2-5

[10]
CMCTS stabilized Fe3O4 particles with extremely low toxicity as highly efficient near-infrared photothermal agents for in vivo tumor ablation.

Nanoscale. 2013-9-7

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