Ng Shean-Yeaw, Kamada Takashi, Suleiman Monica, Vairappan Charles Santhanaraju
a Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation , Universiti Malaysia Sabah , Kota Kinabalu , Malaysia.
Nat Prod Res. 2018 Aug;32(15):1832-1837. doi: 10.1080/14786419.2017.1405409. Epub 2017 Nov 20.
The Bornean liverwort Gottschelia schizopleura was investigated phytochemically for the first time. Two new and four previously known clerodane-type diterpenoids were isolated from the MeOH extract of G. schizopleura through a series of chromatographic techniques. The structures of the new metabolites were established by analyses of their spectroscopic data (1D NMR, 2D NMR, HRESIMS and IR). All the isolated compounds 1-6 were tested against human promyelocytic leukaemia (HL-60), human colon adenocarcinoma (HT-29) and Mus musculus skin melanoma (B16-F10). Compound 1 and 2 showed active inhibition against HL-60 and B16-F10 cells.
