Kamada Takashi, Johanis Mary Lyn, Ng Shean-Yeaw, Phan Chin-Soon, Suleiman Monica, Vairappan Charles S
Department of Materials and Life Science, Faculty of Science and Technology, Shizuoka Institute of Science and Technology, 2200-2 Toyosawa, Fukuroi, Shizuoka, 437-8555, Japan.
Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88400, Kota Kinabalu, Sabah, Malaysia.
Nat Prod Bioprospect. 2020 Feb;10(1):51-56. doi: 10.1007/s13659-020-00232-6. Epub 2020 Feb 15.
New bioactive 13-epi-neoverrucosane diterpenoid, 5β-acetoxy-13-epi-neoverrucosanic acid (1) along with three known secondary metabolites, 13-epi-neoverrucosan-5β-ol (2), chelodane (3) and (E)-β-farnesene (4) were isolated from the MeOH extract of east Malaysia's liverwort Pleurozia subinflata. The chemical structure of new compound was elucidated by the analyses of its spectroscopic data (FTIR, NMR and HR-ESI-MS). These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for P. subinflata in Borneo. Compound 3 was widespread in marine sponges however this is the first record for 3 to be found in liverwort. These metabolites were tested for their antifungal potentials against selected fungi from the marine environment. Compound 1 exhibited effective antifungal activity against Lagenidium thermophilum.
从马来西亚东部的叶苔类植物膨叶褶苔的甲醇提取物中分离出了一种新的生物活性13-表-新疣烷二萜类化合物5β-乙酰氧基-13-表-新疣烷酸（1），以及三种已知的次生代谢产物13-表-新疣烷-5β-醇（2）、海石竹烷（3）和（E）-β-法尼烯（4）。通过对其光谱数据（傅里叶变换红外光谱、核磁共振和高分辨电喷雾电离质谱）的分析，阐明了新化合物的化学结构。这些表-新疣烷型化合物似乎是婆罗洲膨叶褶苔显著的化学分类学标记物。化合物3在海洋海绵中广泛存在，但这是首次在叶苔中发现该化合物。测试了这些代谢产物对从海洋环境中挑选出的真菌的抗真菌潜力。化合物1对嗜热拉格霉表现出有效的抗真菌活性。
