Department of Neurochemistry and Molecular Cell Biology, Graduate School of Medical and Dental Sciences, Japan.
Department of Neurochemistry and Molecular Cell Biology, Graduate School of Medical and Dental Sciences, Japan; Transdiciplinary Research Programs, Niigata University, Niigata 951-8510, Japan.
Neurosci Res. 2018 Mar;128:19-24. doi: 10.1016/j.neures.2017.11.002. Epub 2017 Nov 20.
Neuronal development is composed of the complex steps which involve many signaling proteins. On the other hand, there are many proteins highly expressed in the differentiated neurons at developmental stages, but of which physiological functions are not precisely known so far. Glycoprotein 6a (GPM6a) currently belongs to such proteins. This protein has four-transmembrane domains and is a member of proteolipid protein family. Recently, we demonstrated that GPM6a is highly concentrated in lipid rafts of the developing neuron with its palmitoylation, and that this molecule is involved in rapid determination of the neuronal polarity, in response to laminin, an extracellular matrix protein (Honda et al., J Neurosci 37: 4046-64 [2017]). Since lipid rafts are membrane domains enriched in sphingolipids and cholesterol, have lower fluidity than other membrane areas and are believed to be signaling "hot-spots", and here, we discuss the functions of this protein in neuronal lipid raft signaling for neuronal development.
神经元发育由涉及许多信号蛋白的复杂步骤组成。另一方面，在发育阶段，许多高度表达于分化神经元的蛋白质的生理功能目前还不是很清楚。糖蛋白 6a（GPM6a）目前就属于这类蛋白质。该蛋白具有四个跨膜结构域，是蛋白脂质蛋白家族的成员。最近，我们证明 GPM6a 高度集中在发育神经元的脂筏中，通过其棕榈酰化，该分子参与了对外界细胞外基质蛋白层粘连蛋白的快速神经元极性的确定（Honda 等人，J Neurosci 37: 4046-64 [2017]）。由于脂筏是富含神经酰胺和胆固醇的膜区域，其流动性比其他膜区域低，并且被认为是信号“热点”，在这里，我们讨论了该蛋白在神经元脂筏信号中的功能，以促进神经元发育。
